{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:58:20Z","timestamp":1790855900761,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T00:00:00Z","timestamp":1506384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>The prevalence rate of severe fecal incontinence (FI) in adults with spina bifida (SB) is high. The physiological basis of FI in SB has not been clearly established, which contributes to inadequate care. The aim was to better characterize a large cohort of adults with special consideration of anorectal physiology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multidisciplinary team from a French referral centre for SB prospectively collected data on patients who had an anorectal manometry. Factors associated with severe FI (Cleveland clinical incontinence score\u2009\u2265\u20099) were assessed in a multivariate analysis model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 132 adults with SB (sex ratio M\/F: 55 [41.7%]\/77 [58.3%]; mean age of 38.2 [11.6] years old) were assessed. Among these patients, 83\/132 (62.9%) suffered from severe FI. Rectal perception was not evaluable among 17 patients who had a latex allergy. Overall, 29\/115 (25.2%) had maximal tolerable volume (MTV)\u2009&gt;\u2009330\u2009mL or no sensation. The absence of anal canal sensitivity, MVT\u2009&gt;\u2009330\u2009mL and the amplitude of the recto\u2010anal inhibitory reflex (RAIR) &gt;75% after a rectal isovolumic inflation of 50\u2009mL were significantly associated with severe FI in the multivariate analysis model. Neither neurological level nor other neurological features were associated with severe FI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study showed that FI in patients with SB is mainly associated with rectal abnormalities. This should be taken into consideration to improve incontinence management of patients with SB.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.23417","type":"journal-article","created":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T14:56:08Z","timestamp":1506437768000},"page":"1082-1087","source":"Crossref","is-referenced-by-count":9,"title":["Fecal incontinence in patients with spina bifida: The target is the rectum"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7354-6301","authenticated-orcid":false,"given":"Charl\u00e8ne","family":"Brochard","sequence":"first","affiliation":[{"name":"Service des Maladies de l'Appareil Digestif CHRU Pontchaillou, Universit\u00e9 de Rennes 1 Rennes France"},{"name":"Service d'Explorations Fonctionnelles Digestives, CHRU Pontchaillou Universit\u00e9 de Rennes 1 Rennes France"},{"name":"INSERM U1235 Universit\u00e9 de Nantes Nantes France"},{"name":"CIC 1414, INPHY Universit\u00e9 de Rennes 1 Rennes 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