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While psychosocial self\u2010management is efficacious in other pain conditions, its impact on an IC\/BPS population has rarely been studied. The objective of this review is to learn the prevalence and impact of psychosocial factors on IC\/BPS, assess baseline psychosocial characteristics, and offer recommendations for assessment and treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Following PRISMA guidelines, primary information sources were PubMed including MEDLINE, Embase, CINAHL, and GoogleScholar. Inclusion criteria included: (i) a clearly defined cohort with IC\/BPS or with Chronic Pelvic Pain Syndrome provided the IC\/BPS cohort was delineated with quantitative results from the main cohort; (ii) all genders and regions; (iii) studies written in English from 1995 to April 14, 2017; (iv) quantitative report of psychosocial factors as outcome measures or at minimum as baseline characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010four of an initial 642 articles were reviewed. Quantitative analyses demonstrate the magnitude of psychosocial difficulties in IC\/BPS, which are worse than average on all measures, and fall into areas of clinical concern for 7 out of 10 measures. Meta\u2010analyses shows mean Mental Component Score of the Short\u2010Form 12 Health Survey (MCS) of 40.80 (SD 6.25, <jats:italic>N<\/jats:italic>\u2009=\u20092912), where &lt;36 is consistent with severe psychological impairment. Averaged across studies, the population scored in the range seen in clinical depression (CES\u2010D 19.89, SD 13.12, <jats:italic>N<\/jats:italic>\u2009=\u2009564) and generalized anxiety disorder (HADS\u2010A 8.15, SD 4.85, <jats:italic>N<\/jats:italic>\u2009=\u2009465).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The psychological impact of IC\/BPS is pervasive and severe. Existing evidence of treatment is lacking and suggests self\u2010management intervention may be helpful.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.23421","type":"journal-article","created":{"date-parts":[[2017,10,9]],"date-time":"2017-10-09T10:32:38Z","timestamp":1507545158000},"page":"926-941","source":"Crossref","is-referenced-by-count":95,"title":["Psychosocial co\u2010morbidities in Interstitial Cystitis\/Bladder Pain syndrome (IC\/BPS): A systematic review"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9419-8502","authenticated-orcid":false,"given":"Lindsey C.","family":"McKernan","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Vanderbilt University School of Medicine Nashville Tennessee"},{"name":"Department of Physical Medicine and Rehabilitation Vanderbilt University School of Medicine Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin 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