{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:10:36Z","timestamp":1791835836213,"version":"4.3.4"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T00:00:00Z","timestamp":1510704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008485","name":"Schweizerische Akademie der Medizinischen Wissenschaften","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008485","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008492","name":"Swiss Continence Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Our objective was to investigate and compare bladder function in rats assessed by metabolic cage and by urodynamic measurements in fully awake animals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Bladder function of female Lewis rats was investigated in na\u00efve animals by metabolic cage at baseline, 14\u201016 days after bladder catheter and external urethral sphincter electromyography electrode implantation in fully awake animals by urodynamics, and again by metabolic cage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Investigating the same animals (<jats:italic>n<\/jats:italic>\u2009=\u20098), voided volume, average flow, and duration of voiding were similar (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05) in na\u00efve animals measured by metabolic cage and after catheter implantation by urodynamic measurements and by metabolic cage. In na\u00efve animals measured by metabolic cage, voided volumes were significantly different in the light (resting phase) versus the dark (active phase) part of the 24\u2009h cycle (mean difference 0.14\u2009mL, 21%, <jats:italic>P<\/jats:italic>\u2009=\u20090.004, <jats:italic>n<\/jats:italic>\u2009=\u200927).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lower urinary tract function assessed by metabolic cage or by urodynamic meaurements in fully awake rats was indistinguishable. Thus, catheter implantation did not significantly change physiological bladder function. This shows that urodynamic measurements in awake animals are an appropriate approach to study lower urinary tract function in health and disease in animal models, directly paralleling the human diagnostic procedures.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.23455","type":"journal-article","created":{"date-parts":[[2017,11,15]],"date-time":"2017-11-15T13:56:35Z","timestamp":1510754195000},"page":"1266-1271","source":"Crossref","is-referenced-by-count":14,"title":["Urodynamic measurements reflect physiological bladder function in rats"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3540-6794","authenticated-orcid":false,"given":"Marc P.","family":"Schneider","sequence":"first","affiliation":[{"name":"Department of Health Sciences and Technology Brain Research Institute University of Z\u00fcrich ETH Z\u00fcrich Z\u00fcrich Switzerland"},{"name":"Neuro\u2010Urology, Spinal Cord Injury Center and Research Balgrist University Hospital University of Z\u00fcrich Z\u00fcrich Switzerland"},{"name":"Department of Urology University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea M.","family":"Sartori","sequence":"additional","affiliation":[{"name":"Department of Health Sciences and Technology Brain Research Institute University of Z\u00fcrich ETH Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane","family":"Tamp\u00e9","sequence":"additional","affiliation":[{"name":"Department of Health Sciences and Technology Brain Research Institute University of Z\u00fcrich ETH Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selina","family":"Moors","sequence":"additional","affiliation":[{"name":"Department of Health Sciences and Technology Brain Research Institute University of Z\u00fcrich ETH Z\u00fcrich Z\u00fcrich 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