{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:09:06Z","timestamp":1792782546291,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T00:00:00Z","timestamp":1512950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Istanbul Bilim University Medical Faculty Foundation","id":[{"id":"https:\/\/ror.org\/023m35461","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Urethral stricture (US) formation is caused by fibrosis after excessive collagen formation following an injury or trauma to the urethra. In this study, we aimed to evaluate the effects of platelet\u2010rich plasma (PRP) on a urethral injury (UI) model of male rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A UI model was used by applying a coagulation current to the urethras of male rats. There were four groups with six rats in each: control group, PRP applied to naive urethra, UI group, and UI with PRP application. PRP was applied to the urethra after a coagulation current\u2010induced injury as soon as possible. On the 14th day, all rats were sacrificed and urethral tissues were investigated for collagen type I, collagen type III, platelet\u2010derived growth factor\u2010\u03b1, platelet\u2010derived growth factor\u2010\u03b2, and transforming growth factor\u2010\u03b2 using quantitative real\u2010time polymerase chain reaction and Western blot analysis. The effect of urethral damage and healing was evaluated for collagen type I\u2010to\u2010collagen type III ratio.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The collagen type I\u2010to\u2010collagen type III ratio was significantly higher in UI group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05) than in the others, while UI with PRP application group had comparable results with the control group (\n                      <jats:italic>P\u2009<\/jats:italic>\n                      &gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results of this study show that PRP has a preventive effect on stricture formation in a UI model of rats, as shown by its effect on collagen synthesis. Further studies that eventually show the effects of PRP on human tissues are necessary and promising.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.23460","type":"journal-article","created":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T05:46:53Z","timestamp":1512971213000},"page":"1286-1293","source":"Crossref","is-referenced-by-count":25,"title":["Protective effect of platelet\u2010rich plasma on urethral injury model of male rats"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0956-7460","authenticated-orcid":false,"given":"Hasan H.","family":"Tavukcu","sequence":"first","affiliation":[{"name":"Department of Urology School of Medicine Istanbul Bilim University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6mer","family":"Ayta\u00e7","sequence":"additional","affiliation":[{"name":"Department of Urology School of Medicine Istanbul Bilim University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Atu\u011f","sequence":"additional","affiliation":[{"name":"Department of Urology School of Medicine Istanbul Bilim University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bur\u00e7in","family":"Alev","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy Marmara University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zge","family":"\u00c7evik","sequence":"additional","affiliation":[{"name":"Department of Biochemistry School of Pharmacy Cumhuriyet University Sivas Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurdan","family":"B\u00fclb\u00fcl","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology School of Medicine Marmara University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fen","family":"Yarat","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Dentistry Marmara University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eule","family":"\u00c7etinel","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology School of Medicine Marmara University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6ksel","family":"\u015eener","sequence":"additional","affiliation":[{"name":"Department of Pharmacology School of Pharmacy Marmara University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haluk","family":"Kulaks\u0131zo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Urology School of Medicine Istanbul Bilim University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.11.101"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)35879-2"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1984.tb05393.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)47512-4"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)35572-6"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2008.06.013"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.06691.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67610-0"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)66301-X"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.01.061"},{"key":"e_1_2_9_12_1","first-page":"774","article-title":"Epithelial\u2010differentiated adipose\u2010derived stem cells seeded bladder acellular matrix grafts for urethral reconstruction: an animal model","volume":"20","author":"Li H","year":"2014","journal-title":"Tissue Eng Part A"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","unstructured":"LiC LiaoW YangS et al. Urethral reconstruction using bone marrow mesenchymal stem cell\u2010and smooth muscle cell\u2010Seeded bladder acellular matrix. Paper presented at: Transplantation proceedings.2013.","DOI":"10.1016\/j.transproceed.2013.07.055"},{"key":"e_1_2_9_14_1","first-page":"299","article-title":"A standardized research protocol for platelet\u2010rich plasma (PRP) preparation in rats","volume":"8","author":"Messora MR","year":"2011","journal-title":"RSBO (Online)"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2009.06.016"},{"key":"e_1_2_9_16_1","first-page":"41","article-title":"Single injection of platelet\u2010rich plasma in a rat Achilles tendon tear model","volume":"1","author":"Parafioriti A","year":"2011","journal-title":"Muscles Ligaments Tendons J"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2013.09.026"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67105-4"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.21027"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2016.05.016"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-013-2787-9"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.10.132"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2016.02.017"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2016.10.007"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.23460","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.23460","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/nau.23460","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.23460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T02:35:29Z","timestamp":1693967729000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.23460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,11]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1002\/nau.23460"],"URL":"https:\/\/doi.org\/10.1002\/nau.23460","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,11]]}}}