{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:53:02Z","timestamp":1790707982358,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T00:00:00Z","timestamp":1520294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["40159588"],"award-info":[{"award-number":["40159588"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["80595257"],"award-info":[{"award-number":["80595257"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>We investigated the effects of silodosin, an \u03b11A\u2010adrenoceptor (AR) antagonist, on bladder function, especially on non\u2010voiding contractions (NVCs), in a male rat model of bladder outlet obstruction (BOO) by evaluating cystometry (CMG) findings and bladder mechanosensitive single\u2010unit afferent activities (SAAs), related with microcontractions, which may be similar with NVCs and to be of myogenic origin, in the rat model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>BOO was created by partial ligation of the posterior urethra. At 4 days after surgery for BOO, an osmotic pump filled with silodosin (0.12\u2009mg\/kg\/day) or its vehicle was subcutaneously implanted. At 10 days after surgery, CMG and SAAs measurements were taken under conscious and urethane\u2010anesthetized conditions, respectively. The SAAs of A\u03b4\u2010 and C\u2010fibers, which were identified by electrical stimulation of the pelvic nerve and by bladder distention, and intravesical pressure were recorded during constant bladder\u2010filling with saline. Microcontractions were divided into three phases: \u201cascending,\u201d \u201cdescending,\u201d and \u201cstationary.\u201d<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The silodosin\u2010treated group showed a smaller number of NVCs in CMG measurements and lower SAAs of both A\u03b4\u2010 and C\u2010fibers than the vehicle\u2010treated group during bladder\u2010filling. Moreover, in the vehicle\u2010treated groups, the SAAs of both fibers for the ascending phase of microcontractions were significantly higher than those for the other two phases. On the contrary, no significant change was found between any of these three phases in the silodosin\u2010treated group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present results suggest that silodosin inhibits the SAAs of mechanosensitive A\u03b4\u2010 and C\u2010fibers at least partly due to suppressing myogenic bladder contractions in male BOO rats.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.23547","type":"journal-article","created":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T09:02:43Z","timestamp":1520326963000},"page":"1897-1903","source":"Crossref","is-referenced-by-count":8,"title":["Inhibitory effects of silodosin on the bladder mechanosensitive afferent activities and their relation with bladder myogenic contractions in male rats with bladder outlet 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