{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:33:52Z","timestamp":1778693632758,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,31]],"date-time":"2018-03-31T00:00:00Z","timestamp":1522454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","award":["29045"],"award-info":[{"award-number":["29045"]}],"id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Polyuria can lead to progressive chronic bladder overdistension. The impact of polyuria on the bladder has been extensively studied in settings of either diabetes or sucrose diuresis in animals. The goal of this study was to investigate the outcomes of polyuria in a hypertension setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Male Dahl\/SS rats, a hypertension model, received a high\u2010salt or normal diet for 6 weeks. Twenty\u2010four\u2010hour water intake, micturition patterns, and blood pressures were recorded biweekly. Conscious cystometry was carried out at the end of this period. Bladders were collected to measure contractile force and for histological analysis. Paired <jats:italic>t<\/jats:italic>\u2010tests were used to compare changes between Week 0 and Week 6 within each group. Unpaired <jats:italic>t<\/jats:italic>\u2010tests were used for comparisons between groups for all parameters at Week 6.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six weeks of high\u2010salt diet significantly increased water intake and total urine. Blood pressures and volume of urine per micturition was higher in rats on high\u2010salt diet. Bladder overdistension in the high\u2010salt diet group was confirmed by cystometry, shown by a significantly higher bladder capacity, and compliance. No difference in detrusor contractility was observed between both groups. Collagen content was significantly higher in the lamina propria of the high\u2010salt group compared to the normal group, while the opposite was observed in the muscularis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Polyuria, in a hypertension context, leads to changes in bladder morphology and function. These findings help clarify the deleterious clinical impact of polyuria on voiding function, highlighting the variable consequences of bladder overdistension according to the underlying pathology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.23550","type":"journal-article","created":{"date-parts":[[2018,3,31]],"date-time":"2018-03-31T11:05:50Z","timestamp":1522494350000},"page":"1904-1912","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Bladder overdistension with polyuria in a hypertensive rat model"],"prefix":"10.1002","volume":"37","author":[{"given":"Monica","family":"Velasquez Flores","sequence":"first","affiliation":[{"name":"Department of Surgery Division of Urology McGill University Montreal Qu\u00e9bec Canada"},{"name":"Lady Davis Institute for Medical Research Montreal Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abubakr 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