{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T18:15:05Z","timestamp":1784139305331,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,3,31]],"date-time":"2018-03-31T00:00:00Z","timestamp":1522454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004948","name":"Astellas Pharma","doi-asserted-by":"publisher","award":["ISR CZ\u2010110\u2010RG\u201014"],"award-info":[{"award-number":["ISR CZ\u2010110\u2010RG\u201014"]}],"id":[{"id":"10.13039\/501100004948","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess the efficacy and safety of mirabegron in the treatment of neurogenic detrusor overactivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective, multicenter, randomized, double\u2010blind, placebo\u2010controlled study was conducted in three tertiary centers, and included 78 patients suffering from spinal cord injury or multiple sclerosis. Patients were randomized for Mirabegron 50\u2009mg (Group A) or placebo (Group B). Urodynamic parameters, the 24\u2009h pad\u2010weight test, and patient\u2010reported outcomes were assessed. Safety assessments included monitoring the incidence and severity of adverse events. Changes in time and differences between groups were assessed with nonparametric Kruskal\u2010Wallis one\u2010way analysis of variance; <jats:italic>P\u2009<\/jats:italic>\u2264\u20090.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 66 patients were eligible for inclusion in the final analysis. There was a significant increase of volume at the first detrusor contraction (<jats:italic>P<\/jats:italic>\u2009=\u20090.00047) and an improvement in bladder compliance (<jats:italic>P<\/jats:italic>\u2009=\u20090.0041) in the mirabegron group compared with the placebo\u2010treated group, whereas the increase in cystometric capacity did not reach statistical significance (<jats:italic>P<\/jats:italic>\u2009=\u20090.061). There was a clear tendency to reduced urine leakage (<jats:italic>P<\/jats:italic>\u2009=\u20090.056) in Group A. There were significant changes in all the patient\u2010reported outcomes, favoring the mirabegron group. The incidence of drug\u2010related adverse events was 3.13%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Mirabegron (50\u2009mg) improved both urodynamic variables and patient\u2010reported outcomes in patients with NDO. The treatment was tolerated well.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.23566","type":"journal-article","created":{"date-parts":[[2018,3,31]],"date-time":"2018-03-31T11:05:48Z","timestamp":1522494348000},"page":"2226-2233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["Efficacy and safety of mirabegron for the treatment of neurogenic detrusor overactivity\u2014Prospective, randomized, double\u2010blind, placebo\u2010controlled study"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4205-5926","authenticated-orcid":false,"given":"Jan","family":"Krhut","sequence":"first","affiliation":[{"name":"Department of Urology University Hospital Ostrava Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladim\u00edr","family":"Borovi\u010dka","sequence":"additional","affiliation":[{"name":"Department of Urology Thomayer Hospital Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karol\u00edna","family":"B\u00edlkov\u00e1","sequence":"additional","affiliation":[{"name":"Spinal Cord Rehabilitation Unit Rehabilitation Center Kladruby Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radek","family":"S\u00fdkora","sequence":"additional","affiliation":[{"name":"Department of Urology University Hospital Ostrava Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"M\u00edka","sequence":"additional","affiliation":[{"name":"Department of Urology University Hospital Ostrava Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Mokri\u0161","sequence":"additional","affiliation":[{"name":"Department of Urology Thomayer Hospital Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4222-5497","authenticated-orcid":false,"given":"Roman","family":"Zachoval","sequence":"additional","affiliation":[{"name":"Department of Urology Thomayer Hospital Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20798"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2016.206"},{"key":"e_1_2_8_4_1","first-page":"915","article-title":"GENULF: The neurogenic bladder in multiple sclerosis: review of the literature and proposal of management guidelines","volume":"13","author":"de S\u00e8ze M","year":"2007","journal-title":"MultScler"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2016.168"},{"key":"e_1_2_8_6_1","first-page":"16","article-title":"Constipation and LUTS\u2014How do they affect each other","volume":"37","author":"Averbeck MA","year":"2011","journal-title":"IntBraz J Urol"},{"key":"e_1_2_8_7_1","first-page":"623","article-title":"Trospium chloride in patients with neurogenic detrusor overactivity: is dose titration of benefit to the patients","volume":"44","author":"Menarini M","year":"2006","journal-title":"Int J ClinPharmacolTher"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.07.071"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2013.786700"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.11.010"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2015.195"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10066"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.01.007"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(98)00454-3"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2007.02.009"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22945"},{"key":"e_1_2_8_17_1","unstructured":"KovanicPH HuberMB.The Economics of Information\u2010Mathematical Gnostics for Data Analysis. Available at:http:\/\/www.math\u2010gnostics.com 2003 accessed 14. Feb. 2017."},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2012.158"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-13-128"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.02.036"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2008.01.007"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22505"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6777(1998)17:5<499::AID-NAU6>3.0.CO;2-8"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12730"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.12568"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.09.007"},{"key":"e_1_2_8_27_1","first-page":"1","volume-title":"International Standards for Neurological Classifications of Spinal Cord Injury. revised ed","year":"2000"}],"updated-by":[{"DOI":"10.1002\/nau.25272","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000}}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.23566","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.23566","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T06:25:53Z","timestamp":1694931953000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.23566"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,31]]},"references-count":26,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1002\/nau.23566"],"URL":"https:\/\/doi.org\/10.1002\/nau.23566","archive":["Portico"],"relation":{"correction":[{"id-type":"doi","id":"10.1002\/nau.25272","asserted-by":"object"}]},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,31]]},"assertion":[{"value":"2017-09-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}