{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:41:25Z","timestamp":1747150885770,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T00:00:00Z","timestamp":1523923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["225126","257549"],"award-info":[{"award-number":["225126","257549"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To determine the impact of hypothyroidism on the bladder and urethral functions as well as in the activation of the pubococcygeous (Pcm) and bulbospongiosus (Bsm) during micturition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Age\u2010matched control and methimazole\u2010induced hypothyroid female rabbits were used to simultaneously record cystometrograms, urethral pressure, and the reflex activation of Pcm and Bsm during the induced micturition. Urodynamic and urethral variables were measured. Activation or no activation of the Pcm and Bsm during the storage and voiding phases of micturition were categorized as 1 or 0. Significant differences (<jats:italic>P\u2009<\/jats:italic>\u2264\u20090.05) between control and hypothyroid groups were determined with unpaired Student\u2010<jats:italic>t<\/jats:italic> or Mann\u2010Whitney tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One\u2010month induced hypothyroidism increased the residual volume and threshold pressure while the opposite was true for the voided volume, maximal pressure, and voiding efficiency. Urethral pressure was also affected as supported by a notorious augmentation of the urethral resistance, among other changes in the rest of measured variables. Hypothyroidism also affected the reflex activation of the Pcm in the voiding phase of micturition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings demonstrate hypothyroidism impairs the bladder and, urethral functions, and reflex activation of Pcm and Bsm affecting the micturition in female rabbits.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.23594","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T11:39:44Z","timestamp":1523965184000},"page":"2406-2413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hypothyroidism impairs somatovisceral reflexes involved in micturition of female rabbits"],"prefix":"10.1002","volume":"37","author":[{"given":"Octavio","family":"S\u00e1nchez\u2010Garc\u00eda","sequence":"first","affiliation":[{"name":"Depto. de Toxicolog\u00eda de la Reproducci\u00f3n Instituto de Ciencias Benem\u00e9rita Universidad Aut\u00f3noma de Puebla Puebla M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhode","family":"L\u00f3pez\u2010Ju\u00e1rez","sequence":"additional","affiliation":[{"name":"Doctorado en Ciencias Biol\u00f3gicas Universidad Aut\u00f3noma de Tlaxcala Tlaxcala M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Rodr\u00edguez\u2010Castel\u00e1n","sequence":"additional","affiliation":[{"name":"Doctorado en Ciencias Biol\u00f3gicas Universidad Aut\u00f3noma de Tlaxcala Tlaxcala M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dora L.","family":"Corona\u2010Quintanilla","sequence":"additional","affiliation":[{"name":"Centro Tlaxcala de Biolog\u00eda de la Conducta Universidad Aut\u00f3noma de Tlaxcala Tlaxcala 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