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Secondary goals were to assess the effects of rTMS on Lower Urinary Tract Symptoms (LUTS) and Quality of Life (QOL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifteen patients with BPS\/IC were enrolled in this randomized, double\u2010blind, sham stimulation\u2010controlled, crossover study. Patients were treated for 2 weeks with either real\u2010rTMS (for five consecutive days in 20\u2010min sessions) or sham\u2010rTMS (for five consecutive days in 20\u2010min sessions). After a 6\u2010week washout period, the patients who had previously undergone real\u2010rTMS underwent sham\u2010rTMS, and vice versa. Patients were rated at each visit by means of questionnaires on pain, urinary disturbances, depression, and QOL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The statistical analysis revealed significant effects of real\u2010rTMS, when compared with sham\u2010rTMS, on pain (in the VAS, Functional Neuropathic Pelvic Pain, Neuropathic Pain Symptom Inventory, McGill questionnaire, and Central Sensitization Inventory), urinary LUTS (in the Overactive Bladder Questionnaire score, bladder emptying, and daily urinary frequency), and QOL (in the subscores of the SF\u201036 related to physical pain and to emotional status). No serious adverse events were reported during the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of this study show that rTMS applied with an H\u2010coil over the M1 in the area corresponding to the pelvic region in patients with BPS\/IC appears to improve chronic pelvic pain (CPP) and associated urinary disorders.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.23718","type":"journal-article","created":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T07:35:41Z","timestamp":1527147341000},"page":"2678-2687","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Repetitive transcranial magnetic stimulation for chronic neuropathic pain in patients with bladder pain syndrome\/interstitial cystitis"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4071-4393","authenticated-orcid":false,"given":"Mauro","family":"Cervigni","sequence":"first","affiliation":[{"name":"Department of Women's Health and Newborns Interstitial Cystitis Referral Center University Hospital Foundation A. 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