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Mice were evaluated in vivo using urine spot analysis, cystometrograms (CMGs), and external urethral sphincter (EUS) electromyograms (EMGs); and in vitro using histology, immunohistochemistry, and Western blot.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our studies confirm highest expression of p75<jats:sup>NTRs<\/jats:sup> in the detrusor layer of the mouse bladder and lamina II region of the dorsal horn of the lumbar\u2010sacral (L<jats:sub>6<\/jats:sub>\u2010S<jats:sub>1<\/jats:sub>) spinal cord which significantly decreased following SCI. LM11A\u201031 prevented or ameliorated the detrusor sphincter dyssynergia (DSD) and detrusor overactivity (DO) in SCI mice, significantly improving bladder compliance. Furthermore, LM11A\u201031 treatment blocked the SCI\u2010related urothelial damage and bladder wall remodeling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Drugs targeting p75<jats:sup>NTRs<\/jats:sup> can moderate DSD and DO in SCI mice, may identify pathophysiological mechanisms, and have therapeutic potential in SCI patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.23722","type":"journal-article","created":{"date-parts":[[2018,5,28]],"date-time":"2018-05-28T11:06:45Z","timestamp":1527505605000},"page":"2452-2461","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Targeting p75 neurotrophin receptors ameliorates spinal cord injury\u2010induced detrusor sphincter dyssynergia in mice"],"prefix":"10.1002","volume":"37","author":[{"given":"Irina V.","family":"Zabbarova","sequence":"first","affiliation":[{"name":"Department of Medicine University of Pittsburgh Renal\u2010Electrolyte Division Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youko","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pittsburgh Renal\u2010Electrolyte Division Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan J.","family":"Carder","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Wipf","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda S.","family":"Wolf\u2010Johnston","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pittsburgh Renal\u2010Electrolyte Division Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori A.","family":"Birder","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pittsburgh Renal\u2010Electrolyte Division Pittsburgh Pennsylvania"},{"name":"Department of Pharmacology and Chemical Biology University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8070-1664","authenticated-orcid":false,"given":"Naoki","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Chemical Biology University of Pittsburgh Pittsburgh Pennsylvania"},{"name":"Department of Urology University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel E.","family":"Getchell","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pittsburgh Renal\u2010Electrolyte Division Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalifa","family":"Almansoori","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pittsburgh Renal\u2010Electrolyte Division Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Tyagi","sequence":"additional","affiliation":[{"name":"Department of Urology University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher H.","family":"Fry","sequence":"additional","affiliation":[{"name":"School of Physiology Pharmacology and Neuroscience University of Bristol Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6230-2552","authenticated-orcid":false,"given":"Marcus J.","family":"Drake","sequence":"additional","affiliation":[{"name":"School of Physiology Pharmacology and Neuroscience University of Bristol Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4780-7592","authenticated-orcid":false,"given":"Anthony J.","family":"Kanai","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pittsburgh Renal\u2010Electrolyte Division Pittsburgh Pennsylvania"},{"name":"Department of Pharmacology and Chemical Biology University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2401"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2011.05.003"},{"key":"e_1_2_7_4_1","unstructured":"FowlerCJ PanickerJN EmmanuelA. 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