{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:41Z","timestamp":1786978241369,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T00:00:00Z","timestamp":1532649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006310","name":"Medicinska Forskningsr\u00e5det","doi-asserted-by":"publisher","award":["04767"],"award-info":[{"award-number":["04767"]}],"id":[{"id":"10.13039\/501100006310","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The aim of this study was to determine if the duration of the micturition reflex modulation could be prolonged by repeated periods of afferent stimulation in the decorticated rat.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eighteen female Sprague\u2010Dawley rats were used for the study, 10 for intravesical electrical stimulation (IVES), and 8 for Ano\u2010genital pudendal afferents stimulation. Repeated constant flow cystometries were performed with body\u2010warm saline (0.06\u20100.1\u2009mL\/min) at about 10\u2009min interval. The selected afferents were stimulated continuously for 5\u2009min at maximal intensity. The same stimulation was repeated six times with a pause of 5\u2009min between the stimulations. The mean threshold volume of cystometries performed during one hour before and each hour after the stimulation were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After six periods of IVES, the micturition threshold volume decreased to its lowest value (62% of control) during the first hour and remained at 80% 4\u2009h later (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01). Ano\u2010genital afferent stimulation produced a corresponding increase in the micturition threshold volume. The long\u2010lasting poststimulation effect was again observed for more than 5\u2009h. During the first hour the mean threshold volume increased to 211% of controls and it remained at about this level for the entire observation period (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Repeated short periods of stimulation prolonged the modulatory effect well beyond the stimulation period. The findings provide experimental evidence supporting the clinical application of IVES and ano\u2010genital stimulation for treatment of neurogenic urinary bladder dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.23742","type":"journal-article","created":{"date-parts":[[2018,7,28]],"date-time":"2018-07-28T00:05:00Z","timestamp":1532736300000},"page":"2480-2486","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Repeat periods of electrical stimulation prolong the modulation of the micturition reflex in the rat"],"prefix":"10.1002","volume":"37","author":[{"given":"Hui","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Urology The Sixth Affiliated Hospital of Guangzhou Medical University Qingyuan China"},{"name":"Department of Urology Guangdong Provincial Work Injury Rehabilitation Hospital of Jinan University Guangzhou 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