{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T22:57:41Z","timestamp":1770332261146,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T00:00:00Z","timestamp":1536192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To compare severity and characteristics of urologic pain, other urinary symptoms, sexual pain, psychosocial health, and the distribution and intensity of non\u2010urologic pain between men and women with and without Hunner lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All cystoscopies were performed and documented by the same clinician to ensure uniform recognition of Hunner lesions. Intensity of urologic and sexual pain, nocturia, frequency, urgency, and bladder hypersensitivity features were assessed using validated questionnaires and numeric rating scales. The distribution and intensity of non\u2010urologic pain was assessed using self\u2010reported history, a body map diagram, and numeric rating scales. Somatic symptom burden, depression, and anxiety were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 150 participants, 27% (<jats:italic>n<\/jats:italic>\u2009=\u200941) had Hunner lesions (36% of men, 25% of women). Participants with Hunner lesions were significantly older (median age 58 vs 41, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). They reported less intense urologic pain (5 vs 7, <jats:italic>P<\/jats:italic>\u2009=\u20090.024) and more nocturia (ICSI nocturia symptom score: 4 vs 3, <jats:italic>P<\/jats:italic>\u2009=\u20090.007). They also were less likely to have a history of irritable bowel syndrome (15% vs 36%, <jats:italic>P<\/jats:italic>\u2009=\u20090.013) and anxiety attacks (22% vs 44%, <jats:italic>P<\/jats:italic>\u2009=\u20090.013). Close to half of Hunner IC patients had non\u2010urologic pain outside the pelvis. There were no differences in bladder hypersensitivity features (eg, painful bladder filling) between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hunner lesions can be identified in both men and women. There are significant overlaps in terms of their urologic and non\u2010urologic presentation. Further investigation is needed on phenotypic and biological distinction between IC\/BPS with and without Hunner lesions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.23812","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T10:28:47Z","timestamp":1536229727000},"page":"2911-2918","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Comparison of urologic and non\u2010urologic presentation in interstitial cystitis\/bladder pain syndrome patients with and without Hunner lesions"],"prefix":"10.1002","volume":"37","author":[{"given":"Frederick","family":"Van Moh","sequence":"first","affiliation":[{"name":"Division of Urologic Surgery Department of Surgery St. Louis Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Vetter","sequence":"additional","affiliation":[{"name":"Division of Urologic Surgery Department of Surgery St. Louis Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2691-994X","authenticated-orcid":false,"given":"H. Henry","family":"Lai","sequence":"additional","affiliation":[{"name":"Division of Urologic Surgery Department of Surgery St. Louis Missouri"},{"name":"Department of Anesthesiology Washington University School of Medicine St. Louis Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64678-2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)66551-0"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2011.04.030"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(99)80334-3"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2016.04.067"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.08.096"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(01)01166-9"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2007.09.019"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-015-0504-9"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2016.06.089"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.08.013"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.1178"},{"key":"e_1_2_8_14_1","first-page":"4536","article-title":"Assessment of patient outcomes following submucosal injection of triamcinolone for treatment of Hunner's ulcer subtype interstitial cystitis","volume":"16","author":"Cox M","year":"2009","journal-title":"Can J Urol"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.06.023"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.01.086"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.12325"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.03.132"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(99)80333-1"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(02)01829-0"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.05.105"},{"key":"e_1_2_8_22_1","volume-title":"The Brief Pain Inventory: User Guide","author":"Cleeland C","year":"2008"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.01.081"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.01.034"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2490-5-7"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.12370"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.23812","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.23812","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T08:53:36Z","timestamp":1694681616000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.23812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,6]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1002\/nau.23812"],"URL":"https:\/\/doi.org\/10.1002\/nau.23812","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,6]]},"assertion":[{"value":"2018-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}