{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T21:58:10Z","timestamp":1768773490182,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T00:00:00Z","timestamp":1537747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000833","name":"Rosetrees Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000833","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["BiP\u2010UPy; FP7\u2010NMP\u20102012\u2010 LARGE\u2010 310389"],"award-info":[{"award-number":["BiP\u2010UPy; FP7\u2010NMP\u20102012\u2010 LARGE\u2010 310389"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Stress urinary incontinence and pelvic organ prolapse are very common conditions with a proportion of patients requiring implantation of synthetic materials for a durable repair. However increasing numbers of post\u2010surgical complications have been reported related to the use of polypropylene meshes. One hypothesis for the adverse response is poor mechanical matching of the relatively stiff polypropylene mesh particularly as materials in the pelvic floor will need to cope with decades of distension as occurs with increase of intraabdominal pressure on coughing, laughing, or sneezing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study we have undertaken a very simple fatigue testing regime to compare the mechanical abilities of six materials. Four commercial meshes in clinical use and two novel electrospun materials not yet evaluated in the clinic were assessed using a uniaxial tensile test. This was performed on six samples of each dry material and on another six samples of each material after just 3 days of fatigue conditions using a dynamic bioreactor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The four commercial materials showed permanent mechanical deformation after just 3 days of stretching these materials by 25% elongation on a regular dynamic cycle, whereas the two new materials presented more elastic properties without deformation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We suggest that a test as simple as this 3\u2010day fatigue testing is sufficient to distinguish between materials which have already been found to cause complications clinically and newer materials yet to be tested clinically which will hopefully prove more mechanically appropriate for implantation in the pelvic floor.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.23823","type":"journal-article","created":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T17:22:04Z","timestamp":1537809724000},"page":"107-115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Use of a simple in vitro fatigue test to assess materials used in the surgical treatment of stress urinary incontinence and pelvic organ prolapse"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2368-7955","authenticated-orcid":false,"given":"Sabiniano","family":"Roman","sequence":"first","affiliation":[{"name":"Department of Materials Science and Engineering, Kroto Research Institute University of Sheffield Sheffield United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3062-6480","authenticated-orcid":false,"given":"Naside","family":"Mangir","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, Kroto Research Institute University of Sheffield Sheffield United Kingdom"},{"name":"Royal Hallamshire Hospital Sheffield United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucie","family":"Hympanova","sequence":"additional","affiliation":[{"name":"Department of Development and Regeneration, KU Leuven University of Leuven Leuven Belgium"},{"name":"Third Faculty of Medicine, Institute for the Care of the Mother and Child Charles University Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2960-9931","authenticated-orcid":false,"given":"Christopher R.","family":"Chapple","sequence":"additional","affiliation":[{"name":"Royal Hallamshire Hospital Sheffield United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Deprest","sequence":"additional","affiliation":[{"name":"Department of Development and Regeneration, KU Leuven University of Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9188-5769","authenticated-orcid":false,"given":"Sheila","family":"MacNeil","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering, Kroto Research Institute University of Sheffield Sheffield United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,24]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"CD006375","article-title":"Mid\u2010urethral sling operations for stress urinary incontinence in women","volume":"31","author":"Ford AA","year":"2015","journal-title":"Cochrane database Syst Rev"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2007.01548.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-017-3512-3"},{"key":"e_1_2_8_5_1","first-page":"CD004014","article-title":"Surgery for women with anterior compartment prolapse","volume":"11","author":"Maher C","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.06.045"},{"key":"e_1_2_8_7_1","unstructured":"BurkhardF BoschJ CruzF et al. Urinary Incontinence in Adults EAU Guidelines on. Available online at:http:\/\/uroweb.org\/wp\u2010content\/uploads\/14\u2010Urinary\u2010Incontinence_ 2017_web V2\u20132.pdf. Accessed March 6 2018."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-18720-9_9"},{"key":"e_1_2_8_9_1","first-page":"353","article-title":"Obstetrical and gynecological devices; reclassification of surgical mesh for transvaginal pelvic organ prolapse repair; final order","volume":"81","year":"2016","journal-title":"Fed Regist"},{"key":"e_1_2_8_10_1","unstructured":"New EU rules on medical devices to enhance patient safety and modernise public health \u2212 European Commission. Available online at:https:\/\/ec.europa.eu\/growth\/content\/new\u2010eu\u2010rules\u2010medical\u2010devices\u2010enhance\u2010patient\u2010safety\u2010and\u2010modernise\u2010public\u2010health\u20100_en. Accessed March 2 2018."},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.08.002"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.09.073"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.34671"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12081"},{"key":"e_1_2_8_15_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3233\/THC-2004-12106","article-title":"Design of surgical meshes \u2212 an engineering perspective","volume":"12","author":"Pandit AS","year":"2004","journal-title":"Technol Health Care"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2013.04.002"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2014.05.005"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2017.06.032"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2016.02.067"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-006-0214-7"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.34556"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.31401"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100290100019"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eursup.2017.12.002"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-803228-2.00018-0"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-013-2097-8"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.23823","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.23823","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T11:33:59Z","timestamp":1694345639000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.23823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,24]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1002\/nau.23823"],"URL":"https:\/\/doi.org\/10.1002\/nau.23823","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,24]]},"assertion":[{"value":"2018-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}