{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:26:56Z","timestamp":1740104816832,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T00:00:00Z","timestamp":1539302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Idiopathic overactive bladder (OAB) is a prevalent, mystifying disorder with a questionable neurogenic background. We aimed to investigate the possible subtle neuropathic affection underlying its pathogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional cut off study was carried out on a series of 38 females with idiopathic OAB and 22 healthy matched female volunteers. The following was performed: symptom score questionnaire, determination of pudendal nerve terminal motor latency (PNTML), sacral reflexes\u2019 latencies, pudendal somatosensory evoked potentials, and needle electromyography of the external anal and urethral sphincters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A highly significant prolongation of PNTMLs and sacral reflexes latencies among the patients group was detected (<jats:italic>P<\/jats:italic>\u2009\u2265\u20090.001). Pudendal somatosensory evoked potentials showed non\u2010 significance among the two studied groups (<jats:italic>P<\/jats:italic>\u2009\u2265\u20090.05). External anal sphincter neuropathic affection was detected in 27 patients (71%) and external urethral sphincter neuropathic affection was detected in 30 patients (78.9%). The clitoral anal reflex showed the highest sensitivity and specificity among the neurophysiologic tests used in assessing the neuropathic affection (86.7 and 83%, respectively), followed by PNTML (83.3 and 80%, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pudendal neuropathy is the dominating possible attributing factor in the pathogenesis underlying idiopathic OAB. An integrated clinical, urodynamic, and electro\u2010physiological assessment is recommended for evaluation of any overactive bladder patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.23834","type":"journal-article","created":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T11:58:00Z","timestamp":1539345480000},"page":"223-230","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Neurophysiologic study in idiopathic overactive bladder"],"prefix":"10.1002","volume":"38","author":[{"given":"Rowaida H.","family":"Ali","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Physical Medicine and Rehabilitation Ain Shams University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naglaa A.","family":"Gadallah","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Physical Medicine and Rehabilitation Ain Shams University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7597-0867","authenticated-orcid":false,"given":"Abeer K.","family":"El Zohiery","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Physical Medicine and Rehabilitation Ain Shams University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Elwy","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Physical Medicine and Rehabilitation Ain Shams University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ihab","family":"Serag","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Gynaecology and Obstetrics Ain Shams University Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,12]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"113","article-title":"Evaluation and management of overactive bladder: strategies for optimizing care","volume":"8","author":"Willis\u2010Gray MG","year":"2016","journal-title":"Res Rep Urol"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-009-0976-9"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706604"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.03.133"},{"key":"e_1_2_10_6_1","unstructured":"BensonJT Medicine AAoE. 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