{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:15:47Z","timestamp":1770509747525,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T00:00:00Z","timestamp":1540857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006093","name":"Patient-Centered Outcomes Research Institute","doi-asserted-by":"publisher","award":["CER14092138"],"award-info":[{"award-number":["CER14092138"]}],"id":[{"id":"10.13039\/100006093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Clean intermittent catheterization (CIC) is recommended after spinal cord injury (SCI) because it has the least complications, however, CIC has a high discontinuation rate. We hypothesized that bladder botulinum toxin injection or augmentation cystoplasty may improve satisfaction with CIC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The NBRG registry is a multicenter, prospective, observational study asking SCI participants about neurogenic bladder (NGB) related quality of life (QoL). In this study, participants performing CIC as primary bladder management were categorized into 3 groups: (1) CIC alone (CIC); (2) CIC with botulinum toxin (CIC\u2010BTX); and (3) CIC with augmentation cystoplasty (CIC\u2010AUG). Outcomes included <jats:italic>primary<\/jats:italic>: Neurogenic Bladder Symptom Score (NBSS) and SCI\u2010QoL Bladder Management Difficulties, and <jats:italic>secondary<\/jats:italic>: NBSS subdomains (Incontinence, Storage &amp; Voiding, Consequences) and the NBSS final question (satisfaction with urinary function). Multivariable regression, controlling for multiple factors was used to establish differences between the three groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight hundred seventy\u2010nine participants performed CIC as primary bladder management and had the following characteristics: mean age 43.4 (\u00b112.9) and years from injury 13.7 (\u00b110.7), tetraplegia in 284 (32%), and 543 (62%) were men. Bladder management was CIC in 593 (67%), CIC\u2010BTX in 161 (19%), and CIC\u2010AUG in 125(15%). Primary outcomes: CIC\u2010AUG had associated improved total NBSS versus CIC(\u22123.2(\u22125.2 to \u22121.2), <jats:italic>P<\/jats:italic>\u2009=\u20090.001 and CIC\u2010BTX(\u22123.9(\u22126.3 to \u22121.6), <jats:italic>P<\/jats:italic>\u2009=\u20090.001), CIC\u2010AUG also had better SCI\u2010QoL Difficulties scores versus CIC(\u22124(\u22125.48 to \u22122.53, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and CIC\u2010BTX(\u22124.4(\u22126.15 to \u22122.65, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Secondary outcomes: CIC\u2010AUG had associated improved Incontinence and Satisfaction scores versus CIC and CIC\u2010BTX.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Compared to patients performing CIC with or without botulinum toxin treatment, those with augmentation cystoplasty had associated better urinary function and satisfaction with their urinary symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.23849","type":"journal-article","created":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T12:17:45Z","timestamp":1540901865000},"page":"285-294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["The effects of augmentation cystoplasty and botulinum toxin injection on patient\u2010reported bladder function and quality of life among individuals with spinal cord injury performing clean intermittent catheterization"],"prefix":"10.1002","volume":"38","author":[{"given":"Jeremy B.","family":"Myers","sequence":"first","affiliation":[{"name":"Department of Surgery (Urology) University of Utah Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara M.","family":"Lenherr","sequence":"additional","affiliation":[{"name":"Department of Surgery (Urology) University of Utah Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John T.","family":"Stoffel","sequence":"additional","affiliation":[{"name":"Department of Urology University of Michigan Ann Arbor Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean P.","family":"Elliott","sequence":"additional","affiliation":[{"name":"Department of Urology University of Minnesota Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela P.","family":"Presson","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Utah Division of Epidemiology and Biostatistics Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Utah Division of Epidemiology and Biostatistics Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffery","family":"Rosenbluth","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation University of Utah Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amitabh","family":"Jha","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Salt Lake City Veterans Medical Center Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DarshanP","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Surgery (Urology) University of Utah Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blayne","family":"Welk","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Western Ontario London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Neurogenic Bladder Research Group (NBRG. org)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67730-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67800-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2010.06.028"},{"key":"e_1_2_8_5_1","article-title":"A cross\u2010sectional study of the catheter management of neurogenic bladder after traumatic spinal cord injury","author":"Lane GI","year":"2017","journal-title":"Neurourol 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