{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:23:49Z","timestamp":1790195029447,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T00:00:00Z","timestamp":1540252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000133","name":"Agency for Healthcare Research and Quality","doi-asserted-by":"publisher","award":["6K12HS022990\u201004"],"award-info":[{"award-number":["6K12HS022990\u201004"]}],"id":[{"id":"10.13039\/100000133","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR000445"],"award-info":[{"award-number":["UL1TR000445"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The relationship between exposure to abuse and interstitial cystitis\/bladder pain syndrome (IC\/BPS) is well\u2010documented. However, studies have yet to examine posttraumatic stress disorder (PTSD), which develops following exposure to trauma and worsens health outcomes in chronic pain. We aimed to assess the prevalence and impact of PTSD in patients with IC\/BPS, including their relation to genitourinary symptom presentation and widespread pain phenotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We recruited 202 participants with chronic pain from an academic medical center and classified 64 individuals as IC\/BPS based on validated epidemiological criteria. Participants completed self\u2010reported questionnaires assessing trauma exposure, PTSD symptoms, emotional distress, pain, and urinary symptoms. Wilcoxon rank\u2010sum tests assessed study aims comparing IC\/BPS to other chronic pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Although elevated, IC\/BPS trauma exposure rates were equivalent to that of other chronic pain conditions in the sample. Despite this equivalence, in comparison, IC\/BPS patients had significantly higher rates of PTSD symptoms, with 42% meeting provisional diagnostic criteria for PTSD. Among IC\/BPS, those meeting provisional criteria for PTSD had significantly higher incidence of lifetime sexual abuse, childhood trauma, and presentations consistent with the widespread pain phenotype. In IC\/BPS, there was no association between PTSD and genitourinary symptoms, but provisional PTSD was associated with more pain, emotional distress, and poorer quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We recommend that patients with IC\/BPS and widespread pain have ongoing screening and monitoring of PTSD. We recommend using trauma\u2010informed care practices with these patients to increase trust and safety, which could improve treatment compliance and follow\u2010up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.23861","type":"journal-article","created":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T08:37:00Z","timestamp":1540283820000},"page":"353-362","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Posttraumatic stress disorder in interstitial cystitis\/bladder pain syndrome: Relationship to patient phenotype and clinical practice implications"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9419-8502","authenticated-orcid":false,"given":"Lindsey C.","family":"McKernan","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences Vanderbilt University School of Medicine Nashville Tennessee"},{"name":"Department of Physical Medicine and Rehabilitation Vanderbilt University School of Medicine Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin N.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Psychology The Pennsylvania State University State College Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William S.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Department of Urologic Surgery Vanderbilt University School of Medicine Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Michigan Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer S.","family":"Cheavens","sequence":"additional","affiliation":[{"name":"Department of Psychology The Ohio State University Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger R.","family":"Dmochowski","sequence":"additional","affiliation":[{"name":"Department of Urologic Surgery Vanderbilt University School of Medicine Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie J.","family":"Crofford","sequence":"additional","affiliation":[{"name":"Department of Medicine Vanderbilt University School of Medicine Nashville Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.03.132"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2017.03.132"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.02.122"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23421"},{"key":"e_1_2_7_6_1","unstructured":"European Association of Urology. (2017). Guidelines: 2017 Edition. 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