{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:53:15Z","timestamp":1786978395558,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T00:00:00Z","timestamp":1542240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>The use of synthetic mesh in pelvic organ prolapse surgery is being closely scrutinized because of serious concerns regarding life\u2010changing complications such as erosion, pain, infection, bleeding, dyspareunia, organ perforation, and urinary problems. Randomized trials and their syntheses in meta\u2010analysis offer a unique opportunity to assess efficacy and safety. However, outcomes and outcome measures need to be consistently selected, collected, and reported across randomized trials to be effectively combined in systematic reviews.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We evaluated outcome and outcome measure reporting across randomized controlled trials on surgical interventions using synthetic mesh for pelvic organ prolapse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Systematic review of randomized controlled trials using synthetic mesh for the treatment of pelvic organ prolapse. The selected studies were evaluated using Jadad and MOMENT criteria. Outcomes and outcome measures were systematically identified and categorized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventy\u2010one randomized trials were included. Twenty\u2010four different types of mesh were identified. Included trials reported 110 different outcomes and 60 outcome measures. Erosion (40 trials, 78%), pain (29 trials, 56%), bleeding (31 trials, 61%), and dyspareunia (25 trials, 49%) were the most frequently reported outcomes. The longest follow up was 74 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Most randomized trials evaluating surgical interventions using synthetic mesh for pelvic organ prolapse failed to report on clinically important outcomes and to evaluate efficacy and safety over the medium\u2010 and long\u2010term. Developing and implementing a minimum data set, known as a core outcome set, in future vaginal prolapse trials could help address these issues.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.23871","type":"journal-article","created":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T15:58:56Z","timestamp":1542297536000},"page":"509-524","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["A systematic review on reporting outcomes and outcome measures in trials on synthetic mesh procedures for pelvic organ prolapse: Urgent action is needed to improve quality of research"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3491-7792","authenticated-orcid":false,"given":"Thais R.","family":"de Mattos Lourenco","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Urogynaecology Division Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasilis","family":"Pergialiotis","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Surgery and Surgical Research N S Christeas University of Athens, Medical School Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M. N.","family":"Duffy","sequence":"additional","affiliation":[{"name":"Balliol College University of Oxford Oxford United Kingdom"},{"name":"Nuffield Department of Primary Care Health Sciences University of Oxford Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7373-0918","authenticated-orcid":false,"given":"Constantin","family":"Durnea","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Gynaecology Epsom St Helier University Hospitals NHS Trust London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullatif","family":"Elfituri","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Gynaecology Epsom St Helier University Hospitals NHS Trust London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge M.","family":"Haddad","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Urogynaecology Division Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Betschart","sequence":"additional","affiliation":[{"name":"Department of Gynecology University Hospital of Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Falconi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology San Bortolo Hospital Vicenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stergios K.","family":"Doumouchtsis","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Surgery and Surgical Research N S Christeas University of Athens, Medical School Athens Greece"},{"name":"Department of Obstetrics Gynaecology Epsom St Helier University Hospitals NHS Trust London United Kingdom"},{"name":"St George's University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"CHORUS: An International Collaboration for Harmonizing Outcomes, Research and Standards in Urogynaecology and Women's Health","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,15]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"HaylenBT FreemanRM SwiftSE et al. An international urogynecological association (IUGA)\/International Continence Society (ICS) joint terminology and classification of the complications related directly to the insertion of prostheses (meshes implants tapes) & grafts in female pelvic floor surgery.2011Jan."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPV.0000000000000433"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15408"},{"key":"e_1_2_7_5_1","article-title":"A systematic review of outcome and outcome measure reporting in randomized trials evaluating surgical interventions for anterior compartment vaginal prolapse. A call to action to develop a core outcome set","author":"Durnea CM","journal-title":"Int Urogynecol J"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14702"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14969"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.12.039"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.19068"},{"key":"e_1_2_7_10_1","first-page":"7","volume-title":"Methodological Approach to Assessing the Evidence. Reducing Racial and Ethnic Disparities in Reproductive and Perinatal Outcomes the Evidence From Population\u2010Based Interventions","author":"Kennelley J","year":"2011"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-14-70"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12298"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14694"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14438"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2016.04.008"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-013998"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2016.12.009"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjpo-2017-000048"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14219"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001195"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.23871","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.23871","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/nau.23871","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.23871","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T18:45:47Z","timestamp":1694025947000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.23871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,15]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1002\/nau.23871"],"URL":"https:\/\/doi.org\/10.1002\/nau.23871","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,15]]},"assertion":[{"value":"2018-04-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}