{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:36:24Z","timestamp":1781310984738,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T00:00:00Z","timestamp":1545350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Current treatments for interstitial cystitis\/bladder pain syndrome (IC\/BPS) are usually unsuccessful in achieving long\u2010term bladder pain relief and irritable symptom improvement. This study investigated the clinical efficacy of platelet\u2010rich plasma (PRP) intravesical injections on IC\/BPS patients refractory to conventional therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty patients received four monthly intravesical injections of 10\u2009mL PRP extracted from 50\u2009mL of whole blood. The primary end\u2010point was Global Response Assessment (GRA) at 3 months after the 4th PRP injection. Secondary endpoints included changes in O'Leary\u2010Sant symptom score (OSS), visual analog scale (VAS) of pain, daily frequency, nocturia, functional bladder capacity (FBC), maximum flow rate, voided volume, post\u2010void residual volume (PVR) from baseline to 3 months after the 4th PRP injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All 40 patients (37 women and 3 men, aged 55.5\u2009\u00b1\u200911.1 years) completed the four injections and follow\u2010up visits. GRA improved after the 1st PRP injection and the satisfaction persists till the primary end\u2010point. The success rate was 45%, 52%, 70%, 70%, and 67.5% after the 1st, 2nd, 3rd, 4th, and 3 months after the 4th PRP injection, respectively. OSS and VAS also significantly decreased. The PVR did not change after repeated PRP injections, FBC increased, frequency, and nocturia were decreased after PRP injections. All patients were free of urinary tract infection or difficulty urinating.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study demonstrated that repeated intravesical injections of autologous PRP can increase bladder capacity and provide IC symptom improvement in patients with IC\/BPS refractory to conventional therapy. Autologous PRP injection is safe and effective in selected patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.23898","type":"journal-article","created":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T22:40:10Z","timestamp":1545432010000},"page":"703-709","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Intravesical injections of platelet\u2010rich plasma is effective and safe in treatment of interstitial cystitis refractory to conventional treatment\u2014A prospective clinical trial"],"prefix":"10.1002","volume":"38","author":[{"given":"Jia\u2010Fong","family":"Jhang","sequence":"first","affiliation":[{"name":"Department of Urology Buddhist Tzu Chi General Hospital and Tzu Chi University Hualien Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng\u2010Yi","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Buddhist Tzu Chi General Hospital 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