{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:40:55Z","timestamp":1792176055385,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T00:00:00Z","timestamp":1547683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008492","name":"Swiss Continence Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To systematically assess all available evidence on efficacy and safety of desmopressin for treating nocturia in patients with multiple sclerosis (MS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses (PRISMA) statement. Studies were identified by electronic search of Cochrane register, Embase, Medline, Scopus (last search March 3, 2018) and by screening of reference lists and reviews.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After screening of 7015 abstracts, 8 prospective, and 1 retrospective studies were included enrolling a total of 178 patients. The mean patient age ranged between 43 and 51 years. A significant decrease in the number of micturitions per night was reported in 5 studies. An increase in the maximum hours of uninterrupted sleep was only found in two studies. A significant reduction of the volume of nocturnal incontinence was described in one study. The patient satisfaction rates ranged from 56% to 82%. The rate of adverse events was between 0% and 57.9%. The rate of hyponatremia ranged from 0% to 23.5% and other commonly reported adverse events were headache, nausea, fluid retention, rhinitis\/epistaxis, malaise, and swollen ankles. Risk of bias and confounding was relevant in all studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Preliminary data suggest that desmopressin might be effective for treating nocturia in patients with MS. However, adverse events are relatively common, the overall quality of evidence is low and the number of studied patients is very limited. Further studies with newer formulations of desmopressin are highly warranted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.23921","type":"journal-article","created":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T19:10:49Z","timestamp":1547752249000},"page":"563-571","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Desmopressin for treating nocturia in patients with multiple sclerosis: A systematic review: A report from the Neuro\u2010Urology Promotion Committee of the International Continence Society (ICS)"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4997-6763","authenticated-orcid":false,"given":"V\u00e9ronique","family":"Ph\u00e9","sequence":"first","affiliation":[{"name":"M\u00e9decine Sorbonne Universit\u00e9 Department of Urology, Piti\u00e9\u2010Salp\u00eatri\u00e8re Academic Hospital Assistance Publique\u2010H\u00f4pitaux de Paris Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3540-6794","authenticated-orcid":false,"given":"Marc P.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Urology Balgrist University Hospital University of Z\u00fcrich Z\u00fcrich Switzerland"},{"name":"Department of Urology University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8157-2825","authenticated-orcid":false,"given":"Benoit","family":"Peyronnet","sequence":"additional","affiliation":[{"name":"Department of Urology Pontchaillou Hospital Rennes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadim","family":"Abo Youssef","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Urology Balgrist University Hospital University of Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livio","family":"Mordasini","sequence":"additional","affiliation":[{"name":"Department of Urology Cantonal Hospital Lucerne Lucerne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Chartier\u2010Kastler","sequence":"additional","affiliation":[{"name":"M\u00e9decine Sorbonne Universit\u00e9 Department of Urology, Piti\u00e9\u2010Salp\u00eatri\u00e8re Academic Hospital Assistance Publique\u2010H\u00f4pitaux de Paris Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas M.","family":"Bachmann","sequence":"additional","affiliation":[{"name":"Medignition Inc. Research Consultants Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1991-5919","authenticated-orcid":false,"given":"Thomas M.","family":"Kessler","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Urology Balgrist University Hospital University of Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hch105"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458506075651"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.07.071"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638280802639566"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00070-8"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458506071210"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.56.3.245"},{"key":"e_1_2_10_9_1","article-title":"International Continence Society (ICS) report on the terminology for nocutria and nocturnal lower urinary tract function","author":"Hashim H","journal-title":"Neurourol Urodynam"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1191\/135248506ms1320oa"},{"key":"e_1_2_10_11_1","first-page":"49","volume-title":"Handbook of Clinical Neurology","author":"R K","year":"1985"},{"key":"e_1_2_10_12_1","first-page":"17","article-title":"The underestimated impact of nocturia on quality of life","volume":"2005","author":"Stanley N","journal-title":"Eur Urol Suppl"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1994.tb07116.x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2010.09763.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2011.10806.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.07.004"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.10.100"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.13431"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-103-2-228"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)92467-9"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003830050317"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.46.9.854"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-151-4-200908180-00135"},{"key":"e_1_2_10_24_1","unstructured":"ViswanathanM AnsariMT BerkmanND et al. Assessing the Risk of Bias of Individual Studies in Systematic Reviews of Health Care Interventions. Methods Guide for Effectiveness and Comparative Effectiveness Reviews. Rockville (MD) 2008."},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta7270"},{"key":"e_1_2_10_26_1","volume-title":"Cochrane handbook for systematic reviews of interventions v.5.1.0","author":"Higgins JPT","year":"2011"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-007-9232-8"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/135245859900500i608"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.65.5.778"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1996.00550120082020"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1996.tb00035.x"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1995.tb07745.x"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365599009180373"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2018.04.005"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2016.10.112"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2015.02.043"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.23921","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.23921","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/nau.23921","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.23921","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T22:45:43Z","timestamp":1694040343000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.23921"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,17]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1002\/nau.23921"],"URL":"https:\/\/doi.org\/10.1002\/nau.23921","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,17]]},"assertion":[{"value":"2018-09-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}