{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T07:03:43Z","timestamp":1789455823906,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess the efficacy of salt reduction for improving nocturia in patients with high salt intake.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Changes in lower urinary symptoms and frequency volume chart by salt intake (men: 8\u2009g\/day; women: \u22657\u2009g\/day) were analyzed in this prospective study. Patients were instructed to use a brochure for salt intake restriction via interview once every four weeks. The daily salt intake was estimated by using spot urine samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two\u2010hundred twenty\u2010three (69.5%) patients were successful in reducing their daily salt intake (S group), whereas 98 (30.5%) patients failed to reduce their salt intake (F group). In the S group, nocturia improved from 2.3\u2009\u00b1\u20090.9 to 1.4\u2009\u00b1\u20091.0, and nocturnal polyuria index (NPi) improved from 30.2\u2009\u00b1\u20097.5 to 27.7\u2009\u00b1\u20097.3% (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). In the Core Lower Urinary Tract Symptom Score (CLSS) of the S group, Q3 (urgency) improved from 1.0\u2009\u00b1\u20091.0 to 0.9\u2009\u00b1\u20091.0 (<jats:italic>P<\/jats:italic>\u2009=\u20090.001); Q1 (diurnal frequency) (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and Q2 (nocturia) also improved (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Moreover, the quality of life parameter improved significantly (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The patients in the F group did not have improvements in any symptom during the study period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with nocturia who also have high salt intake should be advised to reduce their salt intake, as a lifestyle modification. Our results support the importance of randomized clinical trials with larger populations and the appropriate inclusion\/exclusion criteria to conclude the clinical usefulness of salt reduction in this patient cohort.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.23929","type":"journal-article","created":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T15:05:04Z","timestamp":1549033504000},"page":"927-933","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Effect of salt intake reduction on nocturia in patients with excessive salt intake"],"prefix":"10.1002","volume":"38","author":[{"given":"Tomohiro","family":"Matsuo","sequence":"first","affiliation":[{"name":"Department of Urology Nagasaki University Graduate School of Biomedical Sciences Nagasaki 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