{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:27:48Z","timestamp":1762507668522,"version":"3.37.3"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T00:00:00Z","timestamp":1551916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870523"],"award-info":[{"award-number":["81870523"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>We investigated the effects of sacral neuromodulation using the new six\u2010contact electrode vs the four\u2010contact electrode in pigs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Randomly, a six\u2010contact electrode was implanted in eight pigs in one side of the third sacral (S3) foramen, and a four\u2010contact electrode was implanted in the other side using the same method. Using an external neurostimulator, the number of contact points (sensitive voltage\u2009\u2264\u20092\u2009V) of both electrodes (SacralStim and InterStim systems) was calculated. Cystometry was performed by infusing normal saline or acetic acid. Then sacral neuromodulation with the SacralStim and InterStim systems was induced at a voltage at which we could observe perianal and\/or tail movement. Multiple cystometrograms were performed to determine the effects of the two systems on the micturition reflex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean number of sensitive points of six\u2010contact electrodes of the SacralStim system (2.63\u2009\u00b1\u20090.32) was higher than that of the quadripolar\u2010lead electrodes of the InterStim system (1.38\u2009\u00b1\u20090.18), and the difference was statistically significant (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Acetic acid\u2010induced bladder overactivity significantly reduced bladder capacity to 54.89%\u2009\u00b1\u20094.7% of the normal saline control level. During acetic acid infusion, sacral neuromodulation with the SacralStim system suppressed bladder overactivity and significantly increased bladder capacity to 70.41%\u2009\u00b1\u20095.4% of the normal saline control level, compared with the acetic acid level (\n<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Moreover, sacral neuromodulation with the InterStim system also significantly increased bladder capacity to 69.63%\u2009\u00b1\u20095.3% of the normal saline control level, compared with the acetic acid level (\n<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). No significant differences were found in the results obtained using the two systems (\n<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The six\u2010contact electrode of the SacralStim system had more sensitive points (&lt;2\u2009V) than that of the quadripolar\u2010lead electrode of InterStim system. Potentially, it has more postimplantation programming options and battery savings manifested by lower voltage will increase the longevity of the stimulator. Further studies of sacral neuromodulation with six\u2010contact electrodes in clinical practice are needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.23956","type":"journal-article","created":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T09:58:32Z","timestamp":1551952712000},"page":"1038-1043","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of sacral neuromodulation system with new six\u2010contact points electrode in pigs"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1514-941X","authenticated-orcid":false,"given":"Yiming","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Urology of Capital Medical University China Rehabilitation Research Center, Capital Medical University Beijing China"},{"name":"Beijing Key Laboratory of Neural Injury and Rehabilitation Beijing China"},{"name":"Beijing Institute for Brain Disorders Beijing 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5769-9615","authenticated-orcid":false,"given":"Lingna","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Urology of Capital Medical University China Rehabilitation Research Center, Capital Medical University Beijing China"},{"name":"Beijing Key Laboratory of Neural Injury and Rehabilitation Beijing China"},{"name":"Beijing Institute for Brain Disorders Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoqing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology of Capital Medical University China Rehabilitation Research Center, Capital Medical University Beijing China"},{"name":"Beijing Key Laboratory of Neural Injury and Rehabilitation Beijing China"},{"name":"Beijing Institute for Brain Disorders Beijing 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