{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:26:37Z","timestamp":1740104797623,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The cardiotoxic effects of antimuscarinics constitute a significant restriction in their application in elderly people. Overactive bladder syndrome pharmacotherapy using compounds with cardioprotective properties would seem an ideal solution. The main goal of the study was to assess the impacts of nebivolol\u00a0(NEB) on the activity of BRL 37344\u00a0\u2014\u00a0\u03b23\u2010adrenergic receptor (\u03b23AR) agonist, in the animal model of detrusor overactivity. As both these substances can impact on the cardiovascular system, their effect on the parameters of this system and diuresis was also examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retinyl acetate (RA;\u00a00.75%) solution was used to induce detrusor overactivity in female Wistar rats. BRL and\/or NEB were administered intra\u2010arterially during cystometry in a single dose (2.5 or 5, 0.05 or 0.1\u2009mg\/kg, respectively). In addition, a 24\u2009hours measurement of heart rate, blood pressure, and urine production was carried out.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>NEB (0.05\u2009mg\/kg) and BRL (2.5\u2009mg\/kg) monotherapy proved to have no influence on the cystometric parameters of animals with RA\u2010induced detrusor overactivity. NEB at 0.1\u2009mg\/kg resulted in a drop in the detrusor overactivity index, similarly to BRL at 5\u2009mg\/kg. Coadministration of NEB and BRL, both at ineffective doses, decreased the detrusor overactivity index and ameliorated the nonvoiding contractions. \u03b23AR stimulation proved to induce tachycardia and hypertension. NEB at 0.05\u2009mg\/kg proved to ameliorate detrusor overactivity and have preventive properties against adverse cardiovascular effects of the \u03b23AR agonist.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The combined application of the \u03b23AR agonist and NEB may improve detrusor overactivity without affecting the heart rate, blood pressure, and urine production.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.23993","type":"journal-article","created":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T04:55:22Z","timestamp":1554180922000},"page":"1229-1240","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The influence of nebivolol on the activity of BRL 37344\u00a0\u2014 the \u03b23\u2010adrenergic receptor agonist, in the animal model of detrusor 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