{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:14:19Z","timestamp":1759104859447,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T00:00:00Z","timestamp":1554249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the patterns and predictive factors associated with Hunner lesions (HLs) recurrence in patients with interstitial cystitis (IC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a retrospective analysis of data from patients with IC who underwent transurethral resection and cauterization (TUR\u2010C) of HLs between October 2011 and December 2017. Symptoms were evaluated using the Pelvic Pain and Urgency\/Frequency Patient Symptom Scale (PUF), O'Leary\u2010Sant Interstitial Cystitis Symptom Index, and Visual Analogue Scale (VAS). Patients attended follow\u2010up visits every 3 months; cystoscopy was performed immediately in patients with aggravated symptoms. Recurrence was defined as a VAS score greater than or equal to 4 and HLs recurrence on cystoscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 91 patients were enrolled (25 male, 66 female): median follow\u2010up was 30.6 months. HLs recurrence occurred in 101 sites (53 patients), 21.8% in the previous TUR\u2010C site, 18.8% de novo, and 59.4% at both previous and de novo sites. The recurrence rate was approximately 12.7%, 40%, and 55.2% at 6, 12, and 18 months, respectively. A higher PUF bother score was the only predictive factor of recurrence (odds ratio: 1.142, 95% confidence interval: 1.016\u20101.284, <jats:italic>P<\/jats:italic> = 0.026), with a cut\u2010off value of 7.5 (sensitivity: 67.9%, specificity: 62.5%). In case of late recurrence (&gt;18 months), there was no predictive factor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The HLs recurrence pattern was unpredictable, involving both previous TUR\u2010C and de novo areas. More accurately defining the HLs resection margin may lead to better surgical outcomes but this remains to be proven.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.23998","type":"journal-article","created":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T03:59:45Z","timestamp":1554350385000},"page":"1392-1398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Patterns and predictors of Hunner lesion recurrence in patients with interstitial cystitis"],"prefix":"10.1002","volume":"38","author":[{"given":"Ji\u2010Yeon","family":"Han","sequence":"first","affiliation":[{"name":"Department of Urology Pusan National University Yangsan Hospital Yangsan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Hyun","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Urology Asan Medical Center, University of Ulsan College of Medicine Seoul 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