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Still, <jats:italic>MMP1<\/jats:italic> and <jats:italic>MMP9<\/jats:italic> exhibited a tendency to a higher expression in women with ISD. Concerning the TIMPs expression, no significant statistical differences were found between women with UH and ISD. When evaluating the MMP\/TIMP ratios, we found significant statistical differences between <jats:italic>MMP9<\/jats:italic>\/<jats:italic>TIMP1<\/jats:italic> and <jats:italic>MMP9<\/jats:italic>\/<jats:italic>A2McG<\/jats:italic>. In fact, the correlations of the expression <jats:italic>MMP9<\/jats:italic> with <jats:italic>TIMP1<\/jats:italic> and <jats:italic>A2McG<\/jats:italic> were lost for women with UH. The ratios between <jats:italic>MMP1<\/jats:italic>\/<jats:italic>TIMP1<\/jats:italic> and <jats:italic>MMP1<\/jats:italic>\/<jats:italic>A2McG<\/jats:italic> were similar, although there was a tendency of higher ratio in ISD for <jats:italic>MMP2<\/jats:italic>\/<jats:italic>TIMP2<\/jats:italic> and <jats:italic>MMP2<\/jats:italic>\/<jats:italic>A2McG<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results point toward higher collagenolysis in the suburethral tissue of women with SUI by ISD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24026","type":"journal-article","created":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T05:15:31Z","timestamp":1558070131000},"page":"1533-1539","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Molecular aspects of collagenolysis associated with stress urinary incontinence in women with urethral hypermobility vs intrinsic sphincter deficiency"],"prefix":"10.1002","volume":"38","author":[{"given":"Bercina","family":"Candoso","sequence":"first","affiliation":[{"name":"Department of Urogynecology Centro Hospitalar do Porto\u2014Centro Materno Infantil do Norte Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria J.","family":"Meneses","sequence":"additional","affiliation":[{"name":"Department of Microscopy Laboratory of Cell Biology, Institute of Biomedical Sciences Abel Salazar (ICBAS) and Unit for Multidisciplinary Research in Biomedicine (UMIB),\u00a0University of Porto Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco G.","family":"Alves","sequence":"additional","affiliation":[{"name":"Department of Microscopy Laboratory of Cell Biology, Institute of Biomedical Sciences Abel Salazar (ICBAS) and Unit for Multidisciplinary Research in Biomedicine (UMIB),\u00a0University of Porto Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rio","family":"Sousa","sequence":"additional","affiliation":[{"name":"Department of Microscopy Laboratory of Cell Biology, Institute of Biomedical Sciences Abel Salazar (ICBAS) and Unit for Multidisciplinary Research in Biomedicine (UMIB),\u00a0University of Porto Porto Portugal"},{"name":"Center for Reproductive Genetics Professor Alberto Barros Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4989-5699","authenticated-orcid":false,"given":"Pedro F.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Microscopy Laboratory of Cell Biology, Institute of Biomedical Sciences Abel Salazar (ICBAS) and Unit for Multidisciplinary Research in Biomedicine (UMIB),\u00a0University of Porto Porto Portugal"},{"name":"Department of Genetics, Faculty of Medicine University of Porto Porto Portugal"},{"name":"i3S\u2014Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade Universidade do Porto Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,16]]},"reference":[{"key":"e_1_2_10_1_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365599509180543"},{"issue":"8","key":"e_1_2_10_1_3_1","first-page":"765","article-title":"Histology of the connection between the vagina and levator ani muscles. 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