{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:41:02Z","timestamp":1790732462258,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T00:00:00Z","timestamp":1560124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BPD\/108468\/2015"],"award-info":[{"award-number":["SFRH\/BPD\/108468\/2015"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate if intravesical administration during spinal shock of resiniferatoxin (RTX), an ultrapotent desensitizing agonist of transient receptor potential vanilloid\u20101 (TRPV1), would silence TRPV1\u2010expressing bladder afferents at an early stage of disease progression and modulate neurogenic detrusor overactivity (NDO) emergence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Rats submitted to largely incomplete spinal cord transection at T8\/9 spinal segment were treated with intravesical RTX (50\u2009nM) or its vehicle during spinal shock. Four weeks after spinal lesion, bladder\u2010reflex activity was evaluated by cystometry under urethane anesthesia, after which the bladder, spinal cord, and dorsal root ganglia were collected and processed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found improvements on bladder function several weeks after early intravesical RTX administration, including a marked decrease of intravesical pressures and amplitude of bladder contractions. Such strong long\u2010lasting urodynamic effects resulted from the very potent desensitizing activity of RTX on peripheral terminals of sensory afferents, an effect restricted to the bladder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results support that an early intervention with RTX could potentially attenuate NDO development and ensuing urinary incontinence, with a dramatic impact on the quality of life of spinal cord injury patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24032","type":"journal-article","created":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T12:20:11Z","timestamp":1560169211000},"page":"1540-1550","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effects of early intravesical administration of resiniferatoxin to spinal cord\u2010injured rats in neurogenic detrusor overactivity"],"prefix":"10.1002","volume":"38","author":[{"given":"Raquel","family":"Oliveira","sequence":"first","affiliation":[{"name":"Department of Biomedicine, Experimental Biology Unit, Faculty of Medicine of Porto University of Porto Porto Portugal"},{"name":"Translational NeuroUrology, Instituto de Biologia Molecular e Celular (IBMC) Universidade do Porto Porto Portugal"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S) Universidade do Porto Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3286-0262","authenticated-orcid":false,"given":"Ana","family":"Coelho","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Experimental Biology Unit, Faculty of Medicine of Porto University of Porto Porto Portugal"},{"name":"Translational NeuroUrology, Instituto de Biologia Molecular e Celular (IBMC) Universidade do Porto Porto Portugal"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S) Universidade do Porto Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipa","family":"Franquinho","sequence":"additional","affiliation":[{"name":"Nerve Regeneration Group, Instituto de Biologia Molecular e Celular (IBMC) Universidade do Porto Porto Portugal"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S) Universidade do Porto Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica M.","family":"Sousa","sequence":"additional","affiliation":[{"name":"Nerve Regeneration Group, Instituto de Biologia Molecular e Celular (IBMC) Universidade do Porto Porto Portugal"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S) Universidade do Porto Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Cruz","sequence":"additional","affiliation":[{"name":"Translational NeuroUrology, Instituto de Biologia Molecular e Celular (IBMC) Universidade do Porto Porto Portugal"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S) Universidade do Porto Porto Portugal"},{"name":"Department of Urology Hospital de S. Jo\u00e3o Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8922-5713","authenticated-orcid":false,"given":"C\u00e9lia","family":"D. Cruz","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Experimental Biology Unit, Faculty of Medicine of Porto University of Porto Porto Portugal"},{"name":"Translational NeuroUrology, Instituto de Biologia Molecular e Celular (IBMC) Universidade do Porto Porto Portugal"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S) Universidade do Porto Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,10]]},"reference":[{"key":"e_1_2_9_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(05)52005-3"},{"key":"e_1_2_9_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.07.071"},{"key":"e_1_2_9_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21814"},{"key":"e_1_2_9_1_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2013.60"},{"key":"e_1_2_9_1_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169694"},{"key":"e_1_2_9_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00496-1"},{"key":"e_1_2_9_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2009.08.022"},{"key":"e_1_2_9_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(99)00451-3"},{"key":"e_1_2_9_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.04.012"},{"key":"e_1_2_9_1_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2003.04722.x"},{"key":"e_1_2_9_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2006.04.006"},{"key":"e_1_2_9_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"e_1_2_9_1_14_1","doi-asserted-by":"publisher","DOI":"10.2741\/3651"},{"key":"e_1_2_9_1_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0373-14.2015"},{"key":"e_1_2_9_1_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1999.0814"},{"key":"e_1_2_9_1_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1403.2009.00252.x"},{"key":"e_1_2_9_1_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e3182643c85"},{"key":"e_1_2_9_1_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-200101000-00035"},{"key":"e_1_2_9_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(94)00193-I"},{"key":"e_1_2_9_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00070-8"},{"key":"e_1_2_9_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22549"},{"key":"e_1_2_9_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2003.12.017"},{"key":"e_1_2_9_1_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2014.233"},{"key":"e_1_2_9_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)91145-4"},{"key":"e_1_2_9_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)03171-2"},{"key":"e_1_2_9_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00422-X"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.24032","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/nau.24032","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.24032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T01:20:37Z","timestamp":1694049637000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.24032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,10]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1002\/nau.24032"],"URL":"https:\/\/doi.org\/10.1002\/nau.24032","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,10]]},"assertion":[{"value":"2018-12-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}