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Midurethral slings are the standard of gold standard treatment for female patients with SUI. They have excellent short\u2010term cure rates; however, their efficacy tends to decrease over time and patients often report urinary incontinence recurrence. This paper addresses the applicability of regenerative medicine and tissue engineering for the treatment of SUI in female patients.<\/jats:p><jats:p>Cell\u2010based treatment with periurethral injection of autologous adipose or muscle\u2010derived stem cells have been used for SUI; however, the cure rates and SUI recurrence at 1 year were 40% and 70%, respectively. Novel minimally invasive approaches, such as low\u2010intensity extracorporeal shock wave therapies have shown promising results in SUI animal models. In addition, local injection of growth factors, chemokines, and specific antibodies have shown histological evidence of neoangiogenesis, nerve, and sphincter regeneration in rodents and nonhuman primates with SUI. The use of bioactive factors and proteins secreted by cells, which is called secretomes, have been recognized as key regulators of various mechanisms, such as immunomodulation, angiogenesis, inflammation, apoptosis, and tissue repair.<\/jats:p><jats:p>Emerging therapies aiming to replace or restore tissues and organ functionality may improve the long\u2010term efficacy and in the near future may represent the standard of care for the treatment of SUI.<\/jats:p>","DOI":"10.1002\/nau.24033","type":"journal-article","created":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T05:18:21Z","timestamp":1558070301000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Applicability of regenerative medicine and tissue engineering for the treatment of stress urinary incontinence in female 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