{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T22:31:07Z","timestamp":1765837867555,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T00:00:00Z","timestamp":1559606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Chronic prostatic inflammation is a critical factor that exacerbates lower urinary tract symptoms (LUTS). The serum C\u2010reactive protein (CRP) level is one of the most common markers with which to assess the degree of inflammation, and it has been reported to be related to the severity of LUTS. However, it is not clear whether the CRP level is linked to the magnitude of prostatic inflammation. We evaluated the relationship between the serum CRP level and the magnitude of prostatic inflammation\u00a0and assessed the influence of CRP on the severity of LUTS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated the tissue specimens of 121 benign prostatic hyperplasia (BPH) patients who underwent surgery for BPH and preoperative measurement of the serum CRP level. We quantified the magnitude of prostatic inflammation histologically by determining the number of high endothelial venule (HEV)\u2010like vessels and assessed the relationship between the serum CRP level and the HEV\u2010like vessels. We divided the patients into two groups based on the median serum CRP level and compared the clinical parameters of the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The serum CRP level was correlated with the overactive bladder symptom score, whereas it was not correlated with the number of HEV\u2010like vessels. In filling cystometry and pressure\u2010flow study, the proportion of patients with detrusor overactivity in the higher\u2010CRP group was higher than that in the lower\u2010CRP group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our present study showed that the serum CRP level was significantly associated with storage dysfunction; in contrast, it was not a surrogate marker of prostatic inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24051","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T04:30:24Z","timestamp":1559709024000},"page":"1728-1736","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Serum C\u2010reactive protein level is not associated with prostatic inflammation but with overactive detrusor in patients with benign prostatic 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