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Based on available, but limited evidence from human studies a three\u2010stage model can be hypothesized to characterize BOO\u2010induced bladder remodeling: hypertrophy, compensation (increased detrusor contractility during the voiding phase, often in combination with filling phase detrusor overactivity) followed by the phase of decompensation [detrusor underactivity]. The time between the start of compensation and eventual decompensation seems to be determined by age of onset, severity, and type of obstruction and clinical mitigating factors such as vascular and metabolic problems. Understanding the relative contributions of these factors may allow the development of personalized timelines and probabilities for these obstructed patients.<\/jats:p>","DOI":"10.1002\/nau.24076","type":"journal-article","created":{"date-parts":[[2019,7,6]],"date-time":"2019-07-06T11:53:29Z","timestamp":1562414009000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Do functional changes occur in the bladder due to bladder outlet obstruction? \u2010 ICI\u2010RS 2018"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4833-0538","authenticated-orcid":false,"given":"Ruud","family":"Bosch","sequence":"first","affiliation":[{"name":"Department of Urology University Medical Centre Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Abrams","sequence":"additional","affiliation":[{"name":"Department of Urology Bristol 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