{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:15:24Z","timestamp":1792613724265,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T00:00:00Z","timestamp":1562112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Bladder and bowel dysfunction (BBD) have been recognized in children affected by autism spectrum disorder (ASD), but no consistent information exist\u00a0in adults with the condition. We evaluated the prevalence of BBD and the impact of psychiatric and behavioural profiles in adults affected by ASD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010two adults and 13 children\/teens with ASD and a matched group of typically developing subjects (TD) were prospectively studied. Patients and TD subjects underwent the evaluation of urinary incontinence (UI: diurnal, continuous or intermittent), nocturnal enuresis (NE), and bowel disturbances with the 3\u2010day voiding and bowel diary. In addition, assessment of intellectual disability (ID) and psychiatric and adaptive behaviours with the Neuropsychiatric Inventory Scale (NPI) and the Vineland Adaptive Behaviour Scale 2nd Edition (Vineland\u2010II), was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In adults, any type of incontinence was observed in 81.8% of cases, and NE and intermittent UI in 59.0% and 36.3% of patients, respectively. Faecal incontinence and constipation were detected 36.3% and in 68.1% of cases, respectively. ID was severe in 2 cases and profound in 18; NPI and Vineland\u2010II items most affected were \u201cIrritability\/Lability,\u201d \u201cMotor Activity,\u201d and \u201cAgitation,\u201d and IQ\u2010Socialization and IQ\u2010Communication. Significant relationships were identified between intermittent UI and greater ID (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.02) and high \u201canxiety\u201d (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05), and between NE and high \u201ceuphoria\/elevated mood\u201d (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). These results were similar to those observed in children\/teens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adults with ASD, and greater ID and mood disorders, present with a high prevalence of BBD. A shared pathogenetic mechanism could underlie the co\u2010occurrence of ASD, mood disorders, and BBD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24081","type":"journal-article","created":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T04:18:22Z","timestamp":1562213902000},"page":"1866-1873","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Bladder and bowel dysfunction, adaptive behaviour and psychiatric profiles in adults affected by autism spectrum disorders"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3486-1226","authenticated-orcid":false,"given":"Marilena","family":"Gubbiotti","sequence":"first","affiliation":[{"name":"Department of Medicine University of Perugia  Perugia Italy"},{"name":"Serafico Institute of Assisi, Research Centre \u201cInVita\u201d, Assisi (PG)  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Balboni","sequence":"additional","affiliation":[{"name":"Department of Philosophy, Social and Human Sciences and Education University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Bini","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Elisei","sequence":"additional","affiliation":[{"name":"Serafico Institute of Assisi, Research Centre \u201cInVita\u201d, Assisi (PG)  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Bedetti","sequence":"additional","affiliation":[{"name":"Serafico Institute of Assisi, Research Centre \u201cInVita\u201d, Assisi (PG)  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moreno","family":"Marchiafava","sequence":"additional","affiliation":[{"name":"Serafico Institute of Assisi, Research Centre \u201cInVita\u201d, Assisi (PG)  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Giannantoni","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences and Neurosciences, Functional and Surgical Urology Unit University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,3]]},"reference":[{"key":"e_1_2_6_1_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_6_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.05.011"},{"key":"e_1_2_6_1_4_1","volume-title":"IACAPAP e\u2010Textbook of Child and Adolescent Mental Health","author":"Fuentes J","year":"2014"},{"key":"e_1_2_6_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-016-2722-8"},{"key":"e_1_2_6_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-017-1062-3"},{"key":"e_1_2_6_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.09.101"},{"key":"e_1_2_6_1_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033224"},{"key":"e_1_2_6_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-015-3509-x"},{"key":"e_1_2_6_1_10_1","first-page":"2008","volume-title":"Multiaxial classification of child and adolescent psychiatric disorders: The ICD\u201010 classification of mental and behavioral disorders in children and adolescents","author":"World Health Organization"},{"key":"e_1_2_6_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-017-1020-0"},{"key":"e_1_2_6_1_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.5_Suppl_6.10S"},{"key":"e_1_2_6_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-015-2533-3"},{"key":"e_1_2_6_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22751"},{"key":"e_1_2_6_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10052"},{"key":"e_1_2_6_1_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529709011203"},{"key":"e_1_2_6_1_17_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.175.5.444"},{"key":"e_1_2_6_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19961218)66:3<356::AID-AJMG21>3.0.CO;2-K"},{"key":"e_1_2_6_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22928"},{"key":"e_1_2_6_1_20_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389203718666170911145321"},{"key":"e_1_2_6_1_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00787-017-1062-3"},{"key":"e_1_2_6_1_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2788.2009.01190.x"},{"key":"e_1_2_6_1_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1990.tb16977.x"},{"key":"e_1_2_6_1_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-016-2722-8"},{"key":"e_1_2_6_1_25_1","first-page":"19","article-title":"Anxiety disorders and obsessive\u2010compulsive disorder in individuals with autism spectrum disorder","volume":"30","author":"Postorino V","year":"2017","journal-title":"Curr Psychiatry Rep"},{"key":"e_1_2_6_1_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/luts.12018"},{"key":"e_1_2_6_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22767"},{"key":"e_1_2_6_1_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/1362361315627136"},{"key":"e_1_2_6_1_29_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.111.095737"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.24081","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/nau.24081","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.24081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T10:58:37Z","timestamp":1694257117000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.24081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,3]]},"references-count":28,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1002\/nau.24081"],"URL":"https:\/\/doi.org\/10.1002\/nau.24081","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,3]]},"assertion":[{"value":"2019-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}