{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:13:01Z","timestamp":1782850381262,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T00:00:00Z","timestamp":1562544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK110087"],"award-info":[{"award-number":["R01DK110087"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Current estimated glomerular filtration rate (eGFR) equations may be inaccurate in patients with spina bifida (SB) because of reduced muscle mass and stature. Cross\u2010sectional and longitudinal variability of eGFR were analyzed in these patients across multiple equations, hypothesizing greater variability in creatinine\u2010based than cystatin\u2010C (Cys\u2010C)\u2010based equations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study included children (age, 1\u201017.9 years) and adults (\u226518 years) with SB from 2002\u20102017 at a large SB clinic. Those without all data needed to calculate eGFR were excluded. Four pediatric and three adult eGFR equations were compared for cross\u2010sectional outcomes of eGFR and elevated office blood pressures using chronic kidney disease (CKD) stage classification, and for longitudinal outcome of eGFR slope over time using covariance pattern models accounting for repeated measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and eighty two children and 75 adults had greater than or equal to 1 set of data measurements; 118 and 52, respectively, had greater than or equal to 2 sets. The pediatric bedside Schwartz equation had the highest median eGFR and coefficient of variation. CKD stage classification by eGFR showed large differences across equations in children, with rates of eGFR\u2009&lt;\u200960 and &lt;90\u2009ml\/min\/1.73\u2009m<jats:sup>2<\/jats:sup> ranging from 2%\u20109% and 5%\u201069%, respectively. Only one equation showed a significant inverse association between eGFR and blood pressure. Longitudinally, eGFR slopes over time were different across pediatric equations (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) but not adult equations. The bedside Schwartz equation had a positive eGFR slope; the other Cys\u2010C\u2010containing equations had negative slopes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Creatinine\u2010based equations in children with SB vary considerably from cystatin\u2010C\u2010containing equations in calculating both single point\u2010in\u2010time eGFR values and eGFR trends over time.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24092","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T03:58:28Z","timestamp":1562644708000},"page":"1907-1914","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Estimated kidney function in children and young adults with spina bifida: A retrospective cohort study"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7972-4671","authenticated-orcid":false,"given":"David I.","family":"Chu","sequence":"first","affiliation":[{"name":"Division of Urology Ann &amp; Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois"},{"name":"Center for Healthcare Studies, Institute for Public Health and Medicine Feinberg School of Medicine at Northwestern University  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren C.","family":"Balmert","sequence":"additional","affiliation":[{"name":"Division of Biostatistics Feinberg School of Medicine at Northwestern University  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron M.","family":"Arkin","sequence":"additional","affiliation":[{"name":"Division of Urology Ann &amp; Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Meyer","sequence":"additional","affiliation":[{"name":"Division of Urology Ann &amp; Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilina","family":"Rosoklija","sequence":"additional","affiliation":[{"name":"Division of Urology Ann &amp; Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology Loyola School of Medicine  Hines Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavita S.","family":"Hodgkins","sequence":"additional","affiliation":[{"name":"Division of Kidney Disease Ann &amp; Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Furth","sequence":"additional","affiliation":[{"name":"Division of Nephrology Children's Hospital of Philadelphia  Philadelphia Pennsylvania"},{"name":"Department of Pediatrics Perelman School of Medicine at University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Earl Y.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Division of Urology Ann &amp; Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth B.","family":"Yerkes","sequence":"additional","affiliation":[{"name":"Division of Urology Ann &amp; Robert H. Lurie Children's Hospital of Chicago  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Isakova","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension Feinberg School of Medicine at Northwestern University  Chicago Illinois"},{"name":"Center for Translational Metabolism and Health, Institute for Public Health and Medicine Feinberg School of Medicine at Northwestern University  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,8]]},"reference":[{"key":"e_1_2_9_1_2_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2015.302902"},{"key":"e_1_2_9_1_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2084"},{"key":"e_1_2_9_1_4_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012121197"},{"key":"e_1_2_9_1_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0902066"},{"key":"e_1_2_9_1_6_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015020152"},{"key":"e_1_2_9_1_7_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.09751110"},{"key":"e_1_2_9_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-009-1409-1"},{"key":"e_1_2_9_1_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041031"},{"key":"e_1_2_9_1_10_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008030287"},{"key":"e_1_2_9_1_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000060205.23406.13"},{"key":"e_1_2_9_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.09.093"},{"key":"e_1_2_9_1_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/1817-1737.39574"},{"key":"e_1_2_9_1_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.169"},{"key":"e_1_2_9_1_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2006.04.085"},{"key":"e_1_2_9_1_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_2_9_1_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1114248"},{"key":"e_1_2_9_1_18_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.114.2.S2.555"},{"key":"e_1_2_9_1_19_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197355010-00014"},{"key":"e_1_2_9_1_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-017-3852-8"},{"key":"e_1_2_9_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2016.08.011"},{"key":"e_1_2_9_1_22_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.07480714"},{"key":"e_1_2_9_1_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e3182a92b03"},{"key":"e_1_2_9_1_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2011.02225.x"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.24092","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/nau.24092","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.24092","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T10:59:38Z","timestamp":1694257178000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.24092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,8]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1002\/nau.24092"],"URL":"https:\/\/doi.org\/10.1002\/nau.24092","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,8]]},"assertion":[{"value":"2019-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}