{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T18:49:27Z","timestamp":1768070967607,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T00:00:00Z","timestamp":1563235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Interstitial cystitis\/bladder pain syndrome (IC\/BPS) is a chronic disease, which is difficult to treat. Patients usually seek for new therapies and might not follow\u2010up regularly. This study investigated long\u2010term symptom changes in patients with IC\/BPS, especially in those who were lost to follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled patients with IC\/BPS with a history of &gt;5 years and having comprehensive medical records, baseline IC symptom index and IC problem index, O'Leary\u2010Sant symptom score, and visual analog scale (VAS). A telephone interview was conducted to assess current symptoms with the same questionnaires. A 5\u2010point scale (from \u22121 to 3) was used to grade current treatment outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 198 patients with IC\/BPS with a mean age of 57.4\u2009\u00b1\u200912.2 years were included. At a mean follow\u2010up duration of 16.6\u2009\u00b1\u20099.75 years, 12% of the patients were free of symptoms and 47% exhibited symptom improvement of more than 50%. Totally, 47 (23.7%) patients were lost to follow\u2010up for &gt;5 years, and 151 (76.3%) had a regular follow\u2010up. The patients with\u00a0IC\/BPS who were not regularly followed up had no Hunner's lesion, and had a higher bladder volume (<jats:italic>P<\/jats:italic>\u2009=\u2009.023), higher urine flow (<jats:italic>P<\/jats:italic>\u2009=\u2009.019), and fewer comorbidities (<jats:italic>P<\/jats:italic>\u2009=\u2009.014) than those who had a regular follow\u2010up. The number of treatment modalities was significantly less in the patients who were lost to follow\u2010up (<jats:italic>P<\/jats:italic>\u2009=\u2009.037).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>About half of the patients with IC\/BPS exhibited symptom improvement with time, with or without regular follow\u2010up and receiving a new treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24104","type":"journal-article","created":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T12:49:36Z","timestamp":1563281376000},"page":"1985-1993","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Long\u2010term outcome and symptom improvement in patients with interstitial cystitis\/bladder pain syndrome with or without regular follow\u2010up and treatment"],"prefix":"10.1002","volume":"38","author":[{"given":"Hui\u2010Ling","family":"Yeh","sequence":"first","affiliation":[{"name":"Department of Nursing, Hualien Tzu Chi General Hospital, Buddhist Tzu Chi Medical Foundation Tzu Chi University  Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia\u2010Fong","family":"Jhang","sequence":"additional","affiliation":[{"name":"Department of Urology, Hualien Tzu Chi General Hospital, Buddhist Tzu Chi Medical Foundation Tzu Chi University  Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7466-5510","authenticated-orcid":false,"given":"Yuh\u2010Chen","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Urology Yang Ming Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7165-4771","authenticated-orcid":false,"given":"Hann\u2010Chorng","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Urology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation Tzu Chi University  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