{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T07:57:36Z","timestamp":1772006256283,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T00:00:00Z","timestamp":1569974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the add\u2010on effects of tadalafil in patients with a relatively small benign prostatic enlargement (BPE) treated with tamsulosin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From September 2014 to July 2018, we prospectively studied patients (aged 50 years or more) attending our hospital who had received tamsulosin for small BPE (20\u201340\u2009mL) for 4 weeks at least and still had residual lower urinary tract symptoms (LUTS) with total International Prostate Symptom Scores (IPSS) of at least 8 and IPSS\u2010quality of life scores at least 3. We randomized eligible patients into two groups: one of which received tadalafil 5\u2009mg once daily for 6 weeks, followed by placebo for 6 weeks, and the other of which received placebo followed by tadalafil in the same manner. The patients were reviewed at our outpatient clinic after 2, 6, 8, and 12 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 13 patients in the tadalafil\u2010placebo and 13 in the placebo\u2010tadalafil group. Their median ages (range) were 70 (65\u201085) and 73 (50\u201080) years, prostatic volumes (median) 30.0 (22.0\u201039.7) and 32.0 (20.1\u201039.5)\u2009mL, and total IPSS (median) 17 (10\u201027) and 16 (10\u201024), respectively. The primary endpoints, namely mean changes of total IPSS from baseline, were 1.85 on placebo and \u22123.42 on tadalafil; this difference is statistically significant (difference: \u22121.57; 95% confidence interval: \u22123.00, \u22120.69; <jats:italic>P<\/jats:italic>\u2009=\u2009.032). We encountered no adverse effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Add\u2010on of tadalafil for symptomatic patients with small BPE treated with tamsulosin appears to be effective and safe.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24175","type":"journal-article","created":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T03:05:36Z","timestamp":1570071936000},"page":"237-242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Add\u2010on effects of tadalafil in tamsulosin\u2010treated patients with small benign prostatic enlargement: A randomized, placebo\u2010controlled, double\u2010blind, crossover study"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1144-2755","authenticated-orcid":false,"given":"Hiromitsu","family":"Negoro","sequence":"first","affiliation":[{"name":"Department of Urology Kyoto University Hospital Kyoto Japan"},{"name":"Department of Urology, Faculty of Medicine University of Tsukuba Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Urology Kyoto University Hospital Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shusuke","family":"Akamatsu","sequence":"additional","affiliation":[{"name":"Department of Urology Kyoto University Hospital Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Terada","sequence":"additional","affiliation":[{"name":"Department of Urology Kyoto University Hospital Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Urology Kyoto University Hospital Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Matsui","sequence":"additional","affiliation":[{"name":"Department of Urology Kyoto University Hospital Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Kyoto University Hospital Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Omura","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Kyoto University Hospital Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Yonezawa","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Kyoto University Hospital Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Therapeutics Kyoto University Hospital Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Urology Kyoto University Hospital Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,2]]},"reference":[{"key":"e_1_2_8_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13744"},{"key":"e_1_2_8_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/luts.12144"},{"key":"e_1_2_8_1_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2019.1589452"},{"key":"e_1_2_8_1_5_1","unstructured":"Gravas S Bach T Drake MJ et al: EAU guidelines on management of non\u2010neurogenic male lower urinary tract symptoms (LUTS) incl. benign prostatic obstruction (BPO). 2018.https:\/\/uroweb.org\/wp\u2010content\/uploads\/EAU\u2010Guidelines\u2010on\u2010the\u2010Management\u2010of\u2010Non\u2010neurogenic\u2010Male\u2010LUTS\u20102018\u2010large\u2010text.pdf. Accessed 15 September 2019."},{"key":"e_1_2_8_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.13401"},{"key":"e_1_2_8_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.02.033"},{"key":"e_1_2_8_1_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107593"},{"key":"e_1_2_8_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14669"},{"key":"e_1_2_8_1_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2012.11255.x"},{"key":"e_1_2_8_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.22686"},{"key":"e_1_2_8_1_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms151017204"},{"key":"e_1_2_8_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14205"},{"key":"e_1_2_8_1_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.12410"},{"key":"e_1_2_8_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.13357"},{"key":"e_1_2_8_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2013.05.005"},{"key":"e_1_2_8_1_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-018-0345-4"},{"key":"e_1_2_8_1_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.13489"},{"key":"e_1_2_8_1_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-018-2453-x"},{"key":"e_1_2_8_1_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-014-1255-z"},{"key":"e_1_2_8_1_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2008.00940.x"},{"key":"e_1_2_8_1_22_1","doi-asserted-by":"publisher","DOI":"10.5213\/inj.1734826.413"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.24175","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/nau.24175","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.24175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T00:49:05Z","timestamp":1693615745000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.24175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,2]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1002\/nau.24175"],"URL":"https:\/\/doi.org\/10.1002\/nau.24175","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,2]]},"assertion":[{"value":"2019-08-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}