{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T04:15:55Z","timestamp":1793852155793,"version":"4.6.1"},"reference-count":63,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T00:00:00Z","timestamp":1572307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Sensory information from the lower urinary tract (LUT) is conveyed to the spinal cord to trigger and co\u2010ordinate micturition. However, it is not fully understood how spinal dorsal horn neurons are excited during the voiding reflex. In this study, we developed an in vivo technique allowing recording of superficial dorsal horn (SDH) neurons concurrent with intravesical pressure (IVP) during the micturition cycle in both normal and diabetic rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Lumbosacral dorsal horn neuronal activity and IVP were recorded from urethane\u2010anesthetized naive and streptozotocin (STZ)\u2010induced diabetic rats. Saline was continuously perfused into the urinary bladder through a cannula to induce micturition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We classified SDH neurons into bladder\u2010 and urethral\u2010responsive neurons, based on their responsiveness during the voiding reflex. Bladder\u2010responsive SDH neurons responded to the rapid increase in IVP at the start of voiding. In contrast, urethral\u2010responsive SDH neuronal firing increased at the peak IVP and their firing lasted during the voiding phase (the high\u2010frequency oscillations). Urethral\u2010responsive SDH neurons were more sensitive to capsaicin, received C afferent fiber inputs, and were rarely detected in STZ\u2010diabetes rats. Administration of a cyclohexenoic long\u2010chain fatty alcohol (TAC\u2010302), which is reported to promote neurite outgrowth of peripheral nerves in STZ\u2010diabetic rats, prevented the functional loss of spinal urethral response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sensory information from the bladder and urethra is conveyed separately to different groups of SDH neurons. Functional loss of spinal urethral sensory information through unmyelinated C afferent fibers may contribute to diabetic bladder dysfunction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.24198","type":"journal-article","created":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T00:15:40Z","timestamp":1572394540000},"page":"144-157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Responsiveness of lumbosacral superficial dorsal horn neurons during the voiding reflex and functional loss of spinal urethral\u2010responsive neurons in streptozotocin\u2010induced diabetic rats"],"prefix":"10.1002","volume":"39","author":[{"given":"Tatsuki","family":"Nakagawa","sequence":"first","affiliation":[{"name":"Department of Neurophysiology Hyogo College of Medicine  Nishinomiya Japan"},{"name":"Department of Functional Anatomy, Graduate School of Medical Sciences Kanazawa University  Kanazawa Japan"},{"name":"Department of Information Physiology National Institute for Physiological Sciences  Okazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nozomi","family":"Akimoto","sequence":"additional","affiliation":[{"name":"Department of Information Physiology National Institute for Physiological Sciences  Okazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Hakozaki","sequence":"additional","affiliation":[{"name":"Department of Information Physiology National Institute for Physiological Sciences  Okazaki Japan"},{"name":"Drug Discovery and Development II Taiho Pharmaceutical Co. 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