{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:10:57Z","timestamp":1790946657354,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T00:00:00Z","timestamp":1574035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To obtain objective evidence for the time to onset of action for intravesical lidocaine utilizing exaggerated sympathetic blood\u2010pressure responsiveness in patients with spinal cord injuries (SCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective observational cohort study analyzed blood pressure responses in individuals with SCI at or above T6 who did (lidocaine\u2010instillation group) or did not (control group) receive 10\u2009ml of 2% lidocaine gel instilled through their catheters before routine suprapubic catheter change. Care was taken to minimize any potentially confounding position change or catheter manipulation. Given the potential for C\u2010fiber mediated systolic blood pressure (SBP) increases after SCI, the time to lidocaine's onset of action for blocking these C\u2010fibers (as seen by the decrease in SBP more than and equal to 10 mm\u2009Hg) was assessed with serial blood pressures for 4 to 6\u2009minutes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Blood pressures were evaluated in 32 individuals with SCI (lidocaine\u2010instillation group n\u2009=\u200922, control group n\u2009=\u200910). In the lidocaine\u2010instillation group, 45% individuals demonstrated a sustained decrease in SBP more than and equal to 10 mm\u2009Hg, which occurred at a mean of 98.1\u2009seconds (SD 59\u2009seconds) after lidocaine instillation. Despite up to 6\u2009minutes of serial monitoring, the remainder of the lidocaine\u2010instillation group and the entire control group had SBP fluctuations less than 10 mm\u2009Hg. The serial mean SBPs of those who responded to lidocaine were significantly less than the remaining groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001 for both comparisons).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Utilizing lidocaine's properties to decrease sympathetic\u2010inducing afferents after SCI, the time to onset of action for intravesical lidocaine was found to be approximately 90\u2009seconds. 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