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We examined symptom change within the Symptoms of the Lower Urinary Tract Dysfunction Research Network (LURN) Observational Cohort study identified clusters over time and tested associations with treatments received.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patient\u2010reported LUTS and treatment data were collected at multiple time points between baseline and 12 months from the LURN Observational Cohort study. LUTS severity scores were calculated to summarize changes in symptom reporting over time in previously identified LURN clusters. Repeated measures linear regression models tested adjusted associations between cluster membership and severity scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four\u2010hundred seventeen men and 396 women were classified into improved, unchanged, and worsened symptoms between baseline and 12 months (men: 44.1%, 40.5%, and 15.3%; women: 55.8%, 33.1%, 11.1%, respectively). Improvement in LUTS severity scores varied by cluster (estimated adjusted mean change from baseline range: \u2212.04 change in standard deviations of severity scores (\u0394SD) to \u2212.67 \u0394SD). Prostate surgery was associated with improved severity scores (\u2212.63 \u0394SD) in men, while stress incontinence surgery was associated with improved severity scores (\u2212.88 \u0394SD) in women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Symptom improvement varied by cluster indicating response to therapy differs amongst subtypes of patients with LUTS. The differential improvement of patients in clusters suggests mechanistic differences between clusters and may aid in selecting more targeted treatments in the future.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24219","type":"journal-article","created":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T18:14:02Z","timestamp":1574705642000},"page":"393-402","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Longitudinal changes in symptom\u2010based female and male LUTS clusters"],"prefix":"10.1002","volume":"39","author":[{"given":"Cindy L.","family":"Amundsen","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Duke University Medical Center Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret E.","family":"Helmuth","sequence":"additional","affiliation":[{"name":"Arbor Research Collaborative for Health Ann Arbor 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