{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:33:13Z","timestamp":1778693593134,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T00:00:00Z","timestamp":1574985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670689\/H0515"],"award-info":[{"award-number":["81670689\/H0515"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400689\/H0503"],"award-info":[{"award-number":["81400689\/H0503"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate bladder function patterns following cystostomy and determine the best time window for cystometric evaluation of bladder function in conscious rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Cystostomy was performed in rats of the first seven groups; thereafter, cystometry was performed in the designed time interval. Noncystostomy rats of group 8 voided freely as control. Basal bladder pressure (P<jats:sub>ves.basal<\/jats:sub>), maximum bladder pressure (P<jats:sub>ves.max<\/jats:sub>), bladder threshold pressure (P<jats:sub>ves.thre<\/jats:sub>), voiding interval (VI), bladder contraction duration (CD), bladder compliance (\u0394C), voided volume (VV), postvoiding residual urine (PVR), and bladder capacity (BC) were recorded and compared with cystostomy groups, with VV, PVR, BC compared with the control values. Bladders were collected after the urodynamic study for weighing, hematoxylin\u2010eosin, and Masson staining to investigate pathological changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>P<jats:sub>ves.basal<\/jats:sub>, P<jats:sub>ves.max<\/jats:sub>, and P<jats:sub>ves.thre<\/jats:sub> trended downward, while BC, VI, VV, and \u0394C trended upward on days 1 to 5 postcystostomy. BC and VV significantly decreased on days 1 to 3 postcystostomy compared with control values; on days 5 to 15 postcystostomy, P<jats:sub>ves.basal<\/jats:sub>, P<jats:sub>ves.max<\/jats:sub>, P<jats:sub>ves.thre<\/jats:sub>, VI, VV, BC, and PVR were stable, and BC, VV, and PVR showed no significant differences from the control values. However, on day 21 postcystostomy, BC increased significantly compared with the controls. Bladder weight increased in the cystostomy groups compared with the controls. Pathological analysis showed severe acute bladder inflammation on days 1 to 3, mild inflammation on days 5 to 15, and increased collagen deposition in bladder tissue on day 21 postcystostomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cystometric evaluation of bladder function in conscious rats is best performed on days 5 to 15 postcystostomy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24241","type":"journal-article","created":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T17:50:31Z","timestamp":1575049831000},"page":"565-575","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Changes in bladder function with time following cystostomy in rats"],"prefix":"10.1002","volume":"39","author":[{"given":"Yu Lin","family":"He","sequence":"first","affiliation":[{"name":"Department of Urology, Pediatric Urodynamic Centre, The First Affiliated Hospital of Zhengzhou University Zhengzhou University Zhengzhou China"},{"name":"Henan Joint International Pediatric Urodynamic Laboratory The First Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2793-612X","authenticated-orcid":false,"given":"Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology, Pediatric Urodynamic Centre, The First Affiliated Hospital of Zhengzhou University Zhengzhou University Zhengzhou China"},{"name":"Henan Joint International Pediatric Urodynamic Laboratory The First Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi Bo","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Urology, Pediatric Urodynamic Centre, The First Affiliated Hospital of Zhengzhou University Zhengzhou University Zhengzhou China"},{"name":"Henan Joint International Pediatric Urodynamic Laboratory The First Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong Qun","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Urology, Pediatric Urodynamic Centre, The First Affiliated Hospital of Zhengzhou University Zhengzhou University Zhengzhou China"},{"name":"Henan Joint International Pediatric Urodynamic Laboratory The First Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Urology, Pediatric Urodynamic Centre, The First Affiliated Hospital of Zhengzhou University Zhengzhou University Zhengzhou China"},{"name":"Henan Joint International Pediatric Urodynamic Laboratory The First Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5186-312X","authenticated-orcid":false,"given":"Jian Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology, Pediatric Urodynamic Centre, The First Affiliated Hospital of Zhengzhou University Zhengzhou University Zhengzhou China"},{"name":"Henan Joint International Pediatric Urodynamic Laboratory The First Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing Song","family":"Pu","sequence":"additional","affiliation":[{"name":"Department of Urology, Pediatric Urodynamic Centre, The First Affiliated Hospital of Zhengzhou University Zhengzhou University Zhengzhou China"},{"name":"Henan Joint International Pediatric Urodynamic Laboratory The First Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer D.","family":"Sihoe","sequence":"additional","affiliation":[{"name":"Department of Urology, Pediatric Urodynamic Centre, The First Affiliated Hospital of Zhengzhou University Zhengzhou University Zhengzhou China"},{"name":"Henan Joint International Pediatric Urodynamic Laboratory The First Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Israel","family":"Franco","sequence":"additional","affiliation":[{"name":"Department of Urology Yale University New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0952-118X","authenticated-orcid":false,"given":"Jian Guo","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Urology, Pediatric Urodynamic Centre, The First Affiliated Hospital of Zhengzhou University Zhengzhou University Zhengzhou China"},{"name":"Henan Joint International Pediatric Urodynamic Laboratory The First Affiliated Hospital of Zhengzhou University Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.21108"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20512"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012298"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13591"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2008.10.056"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2015.10.117"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.13225"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0302-2838(03)00353-1"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.21255"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000489987"},{"key":"e_1_2_8_12_1","article-title":"Stachydrine ameliorates cardiac fibrosis through inhibition of angiotensin II\/transformation growth factor \u03b21 fibrogenic axis","volume":"10","author":"Liu X","year":"2019","journal-title":"Front Pharmacol"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10052"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22580"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2000.7391"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.12.048"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(01)01041-X"},{"key":"e_1_2_8_18_1","first-page":"1177","article-title":"Micturition in rats: a chronic model for study of bladder function and effect of anesthetics","volume":"251","author":"Yaksh TL","year":"1986","journal-title":"Am J Physiol"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6777(2000)19:1<87::AID-NAU9>3.0.CO;2-O"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.50.369"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)66518-2"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.21180"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)65211-X"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.12652"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000437336"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2017.11.008"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00043.2014"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)44485-5"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.24241","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/nau.24241","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.24241","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T01:42:43Z","timestamp":1693618963000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.24241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,29]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1002\/nau.24241"],"URL":"https:\/\/doi.org\/10.1002\/nau.24241","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,29]]},"assertion":[{"value":"2019-07-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}