{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:09:10Z","timestamp":1791504550462,"version":"4.3.4"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T00:00:00Z","timestamp":1582761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The aim of this study was to compare long\u2010term outcomes in patients who underwent either native tissue repair or monofilament macroporous polypropylene mesh.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter, randomized trial included\u2014at the end of 5 years follow\u2010up\u2014122 women with severe pelvic organ prolapse, who were randomly assigned to undergo surgical treatment using native tissue repair (native tissue group, n\u2009=\u200959) or synthetic mesh repair (mesh group, n\u2009=\u200963). Cure criterion was when pelvic organ prolapse\u2010quantification (POP\u2010Q) point was \u22640. Quality of life was assessed using the prolapse quality\u2010of\u2010life questionnaire and sexual function with the quality of sexual function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Groups were homogeneous preoperatively with the exception of the previous pelvic surgery variable, which was higher in mesh (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.019). Cure rate was significantly better for mesh group in the anterior compartment (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.002) and in the combination of all compartments (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.001). Native tissue group was significantly better when there was prolapse in the posterior and apical compartment (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.031). In the quality of life analysis, mesh group showed a significant improvement compared with native tissue group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.004). Complications were significantly higher in mesh and recurrence in native tissue. Regarding the reoperation rate, there was no difference between groups, but native tissue had a higher reoperation rate due to recurrence (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.031).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Outcomes in women with severe POP were better with mesh use than native tissue repair, both in the anterior compartment and in the multicompartmental prolapse after 5\u2010year follow\u2010up. Complications were more common in the mesh group and recurrences were more frequent in the native tissue group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.24323","type":"journal-article","created":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T12:08:28Z","timestamp":1582805308000},"page":"1002-1011","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["A multicenter, randomized trial comparing pelvic organ prolapse surgical treatment with native tissue and synthetic mesh: A 5\u2010year follow\u2010up study"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1110-6268","authenticated-orcid":false,"given":"Simone dos Reis B.","family":"da Silveira","sequence":"first","affiliation":[{"name":"Division of Gynecology University Hospital, University of Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antomio PF.","family":"Auge","sequence":"additional","affiliation":[{"name":"Medical Science University of Holy House of Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsanna IK.","family":"Jarmy\u2010Dibella","sequence":"additional","affiliation":[{"name":"Department of Medicine Federal University of Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo FR.","family":"Margarido","sequence":"additional","affiliation":[{"name":"Division of Gynecology University Hospital, University of Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Carramao","sequence":"additional","affiliation":[{"name":"Medical Science University of Holy House of Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudinei","family":"Alves Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Medicine Federal University of Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stergios K.","family":"Doumouchtsis","sequence":"additional","affiliation":[{"name":"Urogynecology Female Pelvic Medicine and Reconstructive Surgery Unit St George's Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmund","family":"Chada Baracat","sequence":"additional","affiliation":[{"name":"Discipline of Gynecology, Clinic Hospital of Sao Paulo University of Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Milhem Haddad","sequence":"additional","affiliation":[{"name":"Discipline of Gynecology, Clinic Hospital of Sao Paulo University of Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22238"},{"issue":"10","key":"e_1_2_7_3_1","first-page":"475","article-title":"Comparison of effectiveness of vaginal and abdominal routes in treating severe uterovaginal or vault prolapse","volume":"45","author":"Ng CC","year":"2004","journal-title":"Singapore Med J"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.2827"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-006-0103-0"},{"issue":"10","key":"e_1_2_7_6_1","first-page":"CD012376","article-title":"Surgery for women with apical vaginal prolapse","author":"Maher C","year":"2016","journal-title":"Cochrane database of systematic reviews"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-014-2501-z"},{"key":"e_1_2_7_8_1","unstructured":"FDA.Update on serious complications associated with transvaginal placement of surgival mesh for pelvic organ prolapse: FDS safety communication.http:\/\/www.fda.gov\/MedicalDevices\/Safety\/AlertandNotices. 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