{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T09:11:41Z","timestamp":1769245901871,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T00:00:00Z","timestamp":1581984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation","award":["TCRD-TPE-106-RT-6"],"award-info":[{"award-number":["TCRD-TPE-106-RT-6"]}]},{"name":"Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation","award":["TCRD-TPE-107-51"],"award-info":[{"award-number":["TCRD-TPE-107-51"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study is to investigate whether ketamine could relieve the social stress (SS)\u2010related bladder dysfunction in mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The FVB mice were randomly assigned to either undergo SS exposure for 60 minutes per day on seven consecutive days for 4 weeks (SS1) or control without SS (SS0). The SS0 were then allocated to single or no injection of ketamine (SS0K1 and SS0K0). In the group of SS1, the SS1 mice were allocated to receive single injection of saline (SS1K0), single dose (SS1K1) or five daily dose of (SS1K5) ketamine injection (25\u2009mg\/kg\/day\/ip) since day 22. In vivo cystometry and tissue bath wire myography were performed on day 29. Serum and urine level of brain\u2010derived neurotrophic factor (BDNF) were measured with enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In mice without social stress exposure, ketamine administration did not significantly affect voiding frequency (<jats:italic>P<\/jats:italic>\u2009&gt;\u2009.05). SS<jats:sub>1<\/jats:sub>K<jats:sub>0<\/jats:sub>, SS<jats:sub>1<\/jats:sub>K<jats:sub>1,<\/jats:sub> and SS<jats:sub>1<\/jats:sub>K<jats:sub>5<\/jats:sub> had significantly lower voiding frequency than that of control (SS<jats:sub>1<\/jats:sub>K<jats:sub>0<\/jats:sub>) (each <jats:italic>n<\/jats:italic>\u2009=\u200915, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). Ketamine administration reversed the trend of decreased voiding frequency in SS<jats:sub>1<\/jats:sub> mice. Stressed mice had significant higher serum level of BDNF that reduced by short\u2010term ketamine. Stressed mice had detrusor overactivity and impaired detrusor contractility which were not reversed by short\u2010term ketamine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Social stress leads to elevated serum BDNF, infrequent voiding, detrusor overactivity, and impaired contractility. Short\u2010term administration of ketamine may improve SS\u2010related infrequent voiding and elevated serum BDNF level. However, ketamine did not improve SS\u2010related bladder dysfunction on urodynamic and myography studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24324","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T12:36:07Z","timestamp":1582029367000},"page":"935-944","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Does ketamine ameliorate the social stress\u2010related bladder dysfunction in mice?"],"prefix":"10.1002","volume":"39","author":[{"given":"Stephen Shei\u2010Dei","family":"Yang","sequence":"first","affiliation":[{"name":"Division of Urology, Taipei Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation New Taipei Taiwan"},{"name":"School of Medicine Buddhist Tzu Chi University Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsi\u2010Hsien","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Urology, Taipei Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation New Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1409-3853","authenticated-orcid":false,"given":"Shang\u2010Jen","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Urology, Taipei Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation New Taipei Taiwan"},{"name":"School of Medicine Buddhist Tzu Chi University Hualien Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/10253890.2014.910650"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00500.2013"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00013.2015"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.04.022"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2017.09.020"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200831050-00002"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.01.057"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145711001064"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90749.2008"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-24239-9"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.24165"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7613.129301"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.112367"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2016.06.012"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2019.05.005"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyx079"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.112378"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-1591.70570"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1309-11.2011"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2012.126"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2007.07.027"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-017-0476-2"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-3623(94)00266-P"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2007.01.038"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2008.08146_2.x"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2009.02361.x"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.04.102"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00607.2014"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-014-0690-5"},{"issue":"2","key":"e_1_2_11_31_1","first-page":"680","article-title":"Enhancement of gamma\u2010aminobutyric acidA receptor activity by alpha\u2010chloralose","volume":"285","author":"Garrett KM","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2011.03.022"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12025"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2012.01.006"},{"issue":"2","key":"e_1_2_11_35_1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1213\/00000539-200202000-00015","article-title":"The anesthetic mechanism of urethane: the effects on neurotransmitter\u2010gated ion channels","volume":"94","author":"Hara K","year":"2002","journal-title":"Anesth Analg"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.01.058"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fnau.24324","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.24324","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/nau.24324","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.24324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T09:25:38Z","timestamp":1694078738000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.24324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,18]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1002\/nau.24324"],"URL":"https:\/\/doi.org\/10.1002\/nau.24324","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"value":"0733-2467","type":"print"},{"value":"1520-6777","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,18]]},"assertion":[{"value":"2019-10-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}