{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T07:24:58Z","timestamp":1789802698313,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T00:00:00Z","timestamp":1586908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 105\u20102628\u2010B\u2010715\u2010003\u2010MY3"],"award-info":[{"award-number":["MOST 105\u20102628\u2010B\u2010715\u2010003\u2010MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 107\u20102320\u2010B\u2010715\u2010005"],"award-info":[{"award-number":["MOST 107\u20102320\u2010B\u2010715\u2010005"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 108\u20102320\u2010B\u2010038\u2010028"],"award-info":[{"award-number":["MOST 108\u20102320\u2010B\u2010038\u2010028"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Though the pressure\u2010volume analysis (PVA), a method based on thermodynamics, is broadly used for assaying cardiac functions, its potential application on the physiology\/pathophysiology of the urinary bladder, which processes resemble thermodynamic cycles to the heart, has not been established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cystometry recording intravesical pressure (IVP) and intravesical volume (IVV) of rhythmic voiding contractions caused by a constant saline infusion (0.04\u2009mL\/min) were carried out in forty urethane\u2010anesthetized female Sprague\u2010Dawley rats, and the PVA was established by plotting IVP against IVV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Pressure\u2010volume points shaped coincident enclosed loops, and loop\u2010associated urodynamic parameters kept stable under a constant infusion rate (0.04\u2009mL\/min). Enhancing preload (by elevating infusion rates to 0.08 and 0.12\u2009mL\/min) increased the area enclosed by the loop (Apv) and shifted loops to the right and slightly upward. Augmenting afterload (by enhancing resistances using 1\/4 and 1\/2 urethra clamping) increased Apv and shifted loops markedly to the right and upward. Without affecting Apv, muscarine (0.01 and 0.1\u2009mM)\u2010induced inotropic states shifted loop to the left and upward that was as opposed to the atropine (0.01 and 0.1\u2009mM)\u2010induced anti\u2010inotropic state.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Not only consistently assayed baseline bladder functions, PVA but also validly measured modified bladder functions due to altered extrinsic environment and intrinsic contractility of the bladder itself. In accompanied by cystometry, PVA could provide a clear concept about the relationship between time, pressure, and volume in the voiding activity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.24363","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T05:50:42Z","timestamp":1586929842000},"page":"1304-1312","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Pressure\u2010volume analysis of rat's micturition cycles in vivo"],"prefix":"10.1002","volume":"39","author":[{"given":"Hsien\u2010Yu","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Medicine Mackay Medical College  New Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Yuan","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Medicine Mackay Medical College  New Taipei 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