{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T19:11:24Z","timestamp":1793473884566,"version":"4.5.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T00:00:00Z","timestamp":1588636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Jo Ann Rooney Women's Health Fund, University of Pennsylvania"},{"name":"Penn PROMOTES Research on Sex and Gender in Health, University of Pennsylvania"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To determine whether childhood adversity is associated with self\u2010reported lower urinary tract symptoms (LUTS) among older adult women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A convenience sample of women (\u226555 years old) who presented to an academic urology practice or who had participated in a previous bladder health prevention study completed questionnaires including the LUTS Tool (on frequency and bother of LUTS), the Adverse Childhood Experiences (ACEs) Questionnaire, the Spielberger State\u2010Trait Anxiety Inventory, and the Center for Epidemiologic Studies Depression Scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average age (SD) of participants (N\u2009=\u2009151) was 64.7 (6.9) years. The total number of ACEs predicted the total number of LUTS, <jats:italic>\u03b2<\/jats:italic>\u2009=\u2009.39 (95% confidence interval [CI]\u2009=\u20090.14, 0.64), <jats:italic>P<\/jats:italic>\u2009=\u2009.003, as well as LUTS frequency, <jats:italic>\u03b2<\/jats:italic>\u2009=\u2009.09 (95% CI\u2009=\u20090.04, 0.13), <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001. ACEs predicted bother for nocturia, <jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.12 (95% CI\u2009=\u20090.03, 0.22), <jats:italic>P<\/jats:italic>\u2009=\u2009.008. Negative affect symptoms did not mediate the relationship between the total number of ACEs and the total number of LUTS. Rather, ACEs predicted LUTS and negative affect symptoms through (at least partially) independent pathways. Analyses controlled for tobacco use, number of vaginal deliveries, hypertension, overactive bladder medication use, body mass index, income, and race because these variables were significantly associated with the total number of ACEs or total number of LUTS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Childhood adversity has an enduring impact on risk for LUTS in adulthood even when controlling for potential confounds and this relationship cannot be explained by negative affect symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24375","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T09:59:56Z","timestamp":1588672796000},"page":"1472-1481","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Enduring impact of childhood adversity on lower urinary tract symptoms in adult women"],"prefix":"10.1002","volume":"39","author":[{"given":"C. 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