{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:19:13Z","timestamp":1790090353872,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T00:00:00Z","timestamp":1589155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Buddhist Tzu Chi General Hospital","award":["IRB107-182-B"],"award-info":[{"award-number":["IRB107-182-B"]}]},{"name":"Chang Gang Medical Foundation-Kaohsiung Branch","award":["CMRPG8H0451"],"award-info":[{"award-number":["CMRPG8H0451"]}]},{"DOI":"10.13039\/501100010425","name":"Tri-Service General Hospital","doi-asserted-by":"crossref","award":["TSGH-C108-059"],"award-info":[{"award-number":["TSGH-C108-059"]}],"id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Extracorporeal shock wave therapy (ESWT) inhibited bladder inflammation and pain in preclinical studies. We assessed ESWT for the treatment of refractory interstitial cystitis\/bladder pain syndrome (IC\/BPS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This double\u2010blind, randomized, placebo\u2010controlled physician\u2010initiated study enrolled 54 patients with IC\/BPS. The patients were assigned to ESWT (N\u2009=\u200924; 2000 shocks, frequency of 3 Hz, and maximum total energy flow density 0.25\u2009mJ\/mm<jats:sup>2<\/jats:sup>) once a week for 4 weeks at suprapubic bladder area or placebo (N\u2009=\u200925; shock wave setting without energy transmission). The primary endpoint was the average changes in O'Leary\u2010Sant symptom scores (OSS) between baseline and 4 weeks after treatment. Secondary endpoints included visual analog scale (VAS, 0\u201010) for pain, the average changes of variables in a 3\u2010day voiding diary, and global response assessment of patient satisfaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 4 weeks posttreatment, both groups were associated with a statistically significant decrease in OSS and VAS pain scale. However, there were no difference in mean change between ESWT vs placebo groups. A significantly higher proportion of patients on ESWT responded as improved in the VAS\u2009\u2265\u20093 vs placebo (<jats:italic>P<\/jats:italic>\u2009=\u2009.035). At 12 weeks posttreatment, improvement in the VAS\u2009\u2265\u20093 was 57.1% vs 19.0% (ESWT vs placebo; <jats:italic>P<\/jats:italic>\u2009=\u2009.011). The finding was associated with an improvement in frequency \u2212\u20091.0\u2009\u00b1\u20092.3 vs 0.7\u2009\u00b1\u20093.2 (ESWT vs placebo; <jats:italic>P<\/jats:italic>\u2009=\u2009.065). No significant adverse events were found in either group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A reduction in pain was discovered in this trial assessing ESWT in patients with IC\/BPS but OSS, which was the primary outcome parameter, was not improved.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24382","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T03:10:09Z","timestamp":1589253009000},"page":"1505-1514","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Pain reduction realized with extracorporeal shock wave therapy for the treatment of symptoms associated with interstitial cystitis\/bladder pain syndrome\u2014A prospective, multicenter, randomized, double\u2010blind, placebo\u2010controlled study"],"prefix":"10.1002","volume":"39","author":[{"given":"Yao\u2010Chi","family":"Chuang","sequence":"first","affiliation":[{"name":"Department of Urology, Center for Shockwave Medicine and Tissue Engineering Kaohsiung Chang Gung Memorial Hospital, College of Medicine, Chang Gung University Taoyuan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"En","family":"Meng","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Surgery Tri\u2010Service General Hospital, National Defense Medical Center Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9480-8972","authenticated-orcid":false,"given":"Michael","family":"Chancellor","sequence":"additional","affiliation":[{"name":"Department of urology Oakland University William Beaumont School of Medicine  Royal Oak Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7165-4771","authenticated-orcid":false,"given":"Hann\u2010Chorng","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Urology Hualien Tzu 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