{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:40:37Z","timestamp":1790732437575,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T00:00:00Z","timestamp":1620691200000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T00:00:00Z","timestamp":1589155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH\u201017\u20101\u20100403"],"award-info":[{"award-number":["W81XWH\u201017\u20101\u20100403"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>We examined the time course of urodynamic changes and the effect of the short or long\u2010term inhibition of brain\u2010derived neurotrophic factor (BDNF) from the early phase after spinal cord injury (SCI) in mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The spinal cord of female C57BL\/6N mice was completely transected. We examined filling cystometry and bladder BDNF levels at 10, 20, and 30 days after SCI, with an additional day\u20105 measurement of BDNF. In a separate group of mice, anti\u2010BDNF antibody (Ab) (10\u2009\u00b5g\/kg\/h) was subcutaneously administered using osmotic pumps from day 3 after SCI, and single\u2010filling cystometry was performed at 10 and 30 days (7 and 27 days of treatment, respectively) after SCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to spinal intact mice, bladder mucosal BDNF was increased at each time point after SCI with the maximal level at day 5 after SCI. Voiding efficiency was lower at each time point after SCI than that of spinal intact mice. The number of non\u2010voiding contractions (NVC) during bladder filling was gradually increased with time. In both 10\u2010 and 30\u2010day SCI groups treated with anti\u2010BDNF Ab, voiding efficiency was improved, and the duration of notch\u2010like intravesical pressure reductions during voiding bladder contractions was prolonged. The number of NVC was significantly decreased only in 30\u2010day SCI mice with 27\u2010day anti\u2010BDNF treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Overexpression of BDNF is associated with the deterioration of voiding efficiency after SCI. The early\u2010started, long\u2010term inhibition of BDNF improved voiding dysfunction and was also effective to reduce the later\u2010phase development of detrusor overactivity after SCI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24385","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T03:17:26Z","timestamp":1589253446000},"page":"1345-1354","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The early, long\u2010term inhibition of brain\u2010derived neurotrophic factor improves voiding, and storage dysfunctions in mice with spinal cord injury"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9587-6798","authenticated-orcid":false,"given":"Naoki","family":"Wada","sequence":"first","affiliation":[{"name":"Department of Renal and Urologic Surgery Asahikawa Medical University Asahikawa Japan"},{"name":"Department of Urology University of Pittsburgh 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