{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T01:15:34Z","timestamp":1755998134512,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T00:00:00Z","timestamp":1591833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Urogyn BV The Netherlands, project no. 19045"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Primary outcome was to evaluate patients' satisfaction after being treated with bulk injection therapy polydimethylsiloxane Urolastic (PDMS\u2010U) for stress urinary incontinence (SUI). Secondary outcomes were: subjective cure, objective cure, severity of SUI symptoms, complications, reintervention rate, and disease\u2010specific quality of life. Furthermore, to determine if outcomes worsened during time\u2010after\u2010treatment (time\u2010frames: 0\u201012, 13\u201024, and \u226525 months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a cross\u2010sectional design, patients treated with PDMS\u2010U were recruited for hospital revisit. The primary outcome, patients' satisfaction, was assessed by the surgical satisfaction questionnaire. Subjective cure, objective cure, and severity of symptoms were assessed by the patients global impression of improvement, standardized cough stress test, and Sandvik severity scale, respectively. Medical charts and face\u2010to\u2010face interviews were used to determine complications and reinterventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>About 110 patients participated, 87 revisited the hospital. Median follow\u2010up was 25 months (interquartile range: 14;35 months). Patients' satisfaction rate was 51%. Subjective and objective cure were respectively 46% and 47%. Most prevalent complications were: urinary retention (22%), pain (15%), and dyspareunia (15%). Exposure and erosion occurred in 7% and 5%, respectively. Reintervention rate of reinjection and excision of bulk material was 6% and 18.0%, respectively. Objective cure significantly worsened during time\u2010after\u2010treatment (<jats:italic>P<\/jats:italic>\u2009=\u2009&lt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>About half of the patients being treated with PDMS\u2010U were satisfied and subjectively cured 2 years after treatment, although the majority still experienced symptoms of SUI. Most complications were mild and transient, however, in 18% excision of bulk material was indicated for severe or persistent complications such as pain, exposure, or erosion.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24417","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T17:50:36Z","timestamp":1591897836000},"page":"1753-1763","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Patients' satisfaction and safety of bulk injection therapy Urolastic for treatment of stress urinary incontinence: A cross\u2010sectional study"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8220-9742","authenticated-orcid":false,"given":"Fenne M.","family":"Casteleijn","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0802-1116","authenticated-orcid":false,"given":"Claudia R.","family":"Kowalik","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Berends","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mija","family":"Blaganje","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Medical Centre Ljubljana  Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mateja","family":"Lasi\u0107 Pecev","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University Medical Centre Ljubljana  Ljubljana Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"van der Linden","sequence":"additional","affiliation":[{"name":"Department of Urology St. Antonius Hospital  Nieuwegein The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra E.","family":"Zwolsman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan\u2010Paul W. R.","family":"Roovers","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Amsterdam UMC University of Amsterdam  Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter","family":"Minnee","sequence":"additional","affiliation":[{"name":"Department of Urology Langeland Hospital  Zoetermeer The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410X.2002.02963.x"},{"issue":"19","key":"e_1_2_7_3_1","first-page":"894","article-title":"[The influence of urinary incontinence on quality of life of community\u2010dwelling, 45\u201070 year old Dutch women]","volume":"144","author":"Vaart CH","year":"2000","journal-title":"Ned Tijdschr Geneeskd"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(00)00232-8"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.03.048"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23807"},{"key":"e_1_2_7_7_1","first-page":"Cd003881","article-title":"Urethral injection therapy for urinary incontinence in women","volume":"7","author":"Kirchin V","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000517"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23299"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/851823"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/724082"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.5173\/ceju.2015.541"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2016.10.011"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-017-3278-7"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/SPV.0000000000000495"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2011.08.171"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.379"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.47.6.497"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20674"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.1930140206"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000452450"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.23877"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-016-3070-0"},{"key":"e_1_2_7_24_1","unstructured":"Council of the European Union EP. 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