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Controls were also recruited and assessed at baseline and 6 months. Extensive clinical data assessing urological symptoms, nonurological pain, chronic overlapping pain syndromes, and psychosocial factors were collected. Diverse biospecimens for biomarker and microbiome studies, quantitative sensory testing (QST) data under multiple stimuli, and structural and functional neuroimaging scans were obtained under a standardized protocol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Recruitment was initiated (July 2015) and completed (February 2019) at six discovery sites. A total of 620 males and females with UCPPS and 73 Controls were enrolled, including 83 UCPPS participants who re\u2010enrolled from the first MAPP Network cohort study (2009\u20102012). Baseline neuroimaging scans, QST measures, and biospecimens were obtained on 578 UCPPS participants. The longitudinal follow\u2010up of the cohort is ongoing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This comprehensive characterization of a large UCPPS cohort with extended follow\u2010up greatly expands upon earlier MAPP Network studies and provides unprecedented opportunities to increase our understanding of UCPPS pathophysiology, factors associated with symptom change, clinically relevant patient phenotypes, and novel targets for future interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.24423","type":"journal-article","created":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T23:56:09Z","timestamp":1592956569000},"page":"1803-1814","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["The Multidisciplinary Approach to The Study of Chronic Pelvic Pain (MAPP) Research Network*: Design and implementation of the Symptom Patterns Study (SPS)"],"prefix":"10.1002","volume":"39","author":[{"given":"J. Quentin","family":"Clemens","sequence":"first","affiliation":[{"name":"Department of Urology Michigan Medicine  Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2417-4879","authenticated-orcid":false,"given":"Jason J.","family":"Kutch","sequence":"additional","affiliation":[{"name":"Division of Biokinesiology and Physical Therapy University of Southern California  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emeran A.","family":"Mayer","sequence":"additional","affiliation":[{"name":"Department of Medicine David Geffen School of Medicine at The University of California  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce D.","family":"Naliboff","sequence":"additional","affiliation":[{"name":"Department of Medicine David Geffen School of Medicine at The University of California  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa V.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Departments of Urology &amp; Obstetrics and Gynecology University of Southern California  Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1237-8364","authenticated-orcid":false,"given":"David J.","family":"Klumpp","sequence":"additional","affiliation":[{"name":"Department of Urology Northwestern University Feinberg School of Medicine  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1324-3517","authenticated-orcid":false,"given":"Anthony J.","family":"Schaeffer","sequence":"additional","affiliation":[{"name":"Department of Urology Northwestern University Feinberg School of Medicine  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8981-5286","authenticated-orcid":false,"given":"Karl J.","family":"Kreder","sequence":"additional","affiliation":[{"name":"Department of Urology University of Iowa Hospitals and Clinics  Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Clauw","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Chronic Pain and Fatigue Research Center University of Michigan  Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2929-8694","authenticated-orcid":false,"given":"Steven E.","family":"Harte","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Chronic Pain and Fatigue Research Center University of Michigan  Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Schrepf","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Chronic Pain and Fatigue Research Center University of Michigan  Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5052-4895","authenticated-orcid":false,"given":"David A.","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Chronic Pain and Fatigue Research Center University of Michigan  Ann Arbor Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald L.","family":"Andriole","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Urologic Surgery Washington University School of Medicine  St Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2691-994X","authenticated-orcid":false,"given":"H. Henry","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Urologic Surgery Washington University School of Medicine  St Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dedra","family":"Buchwald","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Medicine Washington State University Institute for Research and Education to Advance Community Health  Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4974-7378","authenticated-orcid":false,"given":"M. Scott","family":"Lucia","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Colorado Denver  Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6059-2429","authenticated-orcid":false,"given":"Adrie","family":"van Bokhoven","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Colorado Denver  Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Mackey","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative, and Pain Medicine, Division of Pain Medicines Stanford University School of Medicine  Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Moldwin","sequence":"additional","affiliation":[{"name":"Department of Urology Hofstra University School of Medicine, The Arthur Smith Institute for Urology  New Hyde Park New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7369-5435","authenticated-orcid":false,"given":"Michel A.","family":"Pontari","sequence":"additional","affiliation":[{"name":"Department of Urology Lewis Katz School of Medicine at Temple University  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisa J.","family":"Stephens\u2010Shields","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology, and Informatics Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Mullins","sequence":"additional","affiliation":[{"name":"Division of Kidney, Urologic, and Hematologic Diseases National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8099-0988","authenticated-orcid":false,"given":"J. 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