{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:27:14Z","timestamp":1740104834992,"version":"3.37.3"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T00:00:00Z","timestamp":1595980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Sanwa Kagaku Kenkyusho Co, Ltd"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate the effect of anagliptin (Ana), a dipeptidyl peptidase\u20104 (DPP\u20104) inhibitor, on acute ischemia\u2010induced bladder dysfunction in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eight\u2010week\u2010old female Wistar\u2010ST rats were randomly assigned into four groups: (a) sham; (b) ligation (Lig); (c) Lig\u2009+\u2009Ana; and (d) Lig\u2009+\u2009Liraglutide (a glucagon\u2010like peptide\u20101 [GLP\u20101] receptor agonist; Lira). Rats in the Lig, Lig\u2009+\u2009Ana, and Lig\u2009+\u2009Lira groups underwent ligature of the bilateral internal iliac arteries. Ana was orally administered mixed with the CE\u20102 diet. Lira was subcutaneously administered once a day. Blood glucose levels, plasma dipeptidyl peptidase 4 (DPP\u20104) activity, GLP\u20101 levels, and bladder function were measured in all groups. Bladder blood flow was measured in the sham, Lig, and Lig\u2009+\u2009Ana groups, 4 weeks postsurgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No differences in blood glucose levels among the groups were observed. DPP\u20104 activity decreased in the Lig\u2009+\u2009Ana group (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01). GLP\u20101 levels in the Lig\u2009+\u2009Ana and Lig\u2009+\u2009Lira groups were higher than those in the sham and Lig groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01). Intercontraction intervals (ICIs) were longer in the Lig and Lig\u2009+\u2009Lira groups than in the sham group (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05), but similar to those observed in the Lig\u2009+\u2009Ana and sham groups. The Lig group exhibited reduced bladder blood flow relative to the sham group (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01); however, this measure improved in the Lig\u2009+\u2009Ana group (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ana administration improved ICIs and bladder blood flow after acute bladder ischemia through a GLP\u20101 receptor\u2010independent signaling pathway, without altering the blood glucose levels. Therefore, Ana dosing might be useful to prevent ischemia\u2010induced bladder dysfunctions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24449","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T15:41:37Z","timestamp":1596037297000},"page":"1922-1929","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Anagliptin, a dipeptidyl peptidase\u20104 inhibitor, improved bladder function and hemodynamics in rats with bilateral internal iliac artery ligation"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9474-7775","authenticated-orcid":false,"given":"Yuji","family":"Hotta","sequence":"first","affiliation":[{"name":"Department of Hospital Pharmacy Nagoya City University Graduate School of Pharmaceutical Sciences  Nagoya 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