{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:36:55Z","timestamp":1792517815321,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T00:00:00Z","timestamp":1594339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To compare the efficacy of cernitin pollen extract (cernitin) or tadalafil for treating persistent chronic pelvic pain despite \u03b11\u2010blocker monotherapy in men with chronic prostatitis\/chronic pelvic pain syndrome (CP\/CPPS) and lower urinary tract symptoms (LUTS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 100 patients with refractory CP\/CPPS despite ongoing \u03b11\u2010blocker monotherapy were randomized to receive add\u2010on therapy with either cernitin (4 capsules\/day) or tadalafil (5\u2009mg\/d) for 12 weeks. At week 12, changes from baseline in the patients\u2019 CP\/CPPS, LUTS, and voiding function, as assessed using the National Institutes of Health Chronic Prostatitis Symptom Index (NIH\u2010CPSI), the International Prostate Symptom Score (IPSS), and uroflowmetry, respectively, were compared between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The final analysis included 42 and 45 patients in the cernitin and tadalafil groups, respectively. Although the NIH\u2010CPSI total, NIH\u2010CPSI pain sub\u2010score, and NIH\u2010CPSI quality of life sub\u2010score significantly improved in both groups, the cernitin (vs tadalafil) group showed significantly greater improvements in the NIH\u2010CPSI total score (\u22126.8 vs \u22124.6; <jats:italic>P<\/jats:italic>\u2009=\u2009.02) and NIH\u2010CPSI pain sub\u2010score (\u22124.1 vs \u22121.5; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Half (50%) of the patients in the cernitin group showed a reduction greater than 50% in their NIH\u2010CPSI pain sub\u2010score; in the tadalafil group, only four patients (8.9%) showed \u226550% improvement (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). In contrast, the improvement in LUTS was significantly superior in the tadalafil group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both cernitin and tadalafil significantly ameliorated chronic pelvic pain in patients with refractory CP\/CPPS. The add\u2010on of cernitin was more effective than tadalafil for pelvic pain and discomfort.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24454","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T13:18:47Z","timestamp":1594387127000},"page":"1994-2002","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Comparison of cernitin pollen extract vs tadalafil therapy for refractory chronic prostatitis\/chronic pelvic pain syndrome: A randomized, prospective study"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7823-2600","authenticated-orcid":false,"given":"Yoshihisa","family":"Matsukawa","sequence":"first","affiliation":[{"name":"Department of Urology, Graduate School of Medicine Nagoya University  Nagoya 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