{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:15:28Z","timestamp":1790788528298,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011240","name":"Society of Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011240","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009856","name":"L. K. Whittier Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Cerebral stroke is a unique model for studying the role of the brain in lower urinary tract (LUT) control. By its nature, stroke must change the activity of the brain to cause LUT dysfunction. The objective of this study was to describe changes in micturition\u2010related brain activity in patients who develop LUT symptoms (LUTS) after a cerebral stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Healthy controls (HC, n\u2009=\u200910) and patients who developed storage LUTS after a cerebral stroke (n\u2009=\u20097) were recruited. Functional magnetic resonance imaging was used to assess brain activity in each subject. In the task\u2010based block design, blood\u2010oxygen\u2010level\u2010dependent (BOLD) signal was detected during rest, active bladder filling, and bladder voiding. BOLD signal intensity was compared between HCs and stroke subjects during bladder filling, voiding, and voiding initiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Stroke subjects exhibited higher activity in the periaqueductal gray and cerebellum during bladder filling and bladder voiding. HCs exhibited more intense activity in higher centers, such as the cingulate cortex, motor cortex, and the dorsolateral prefrontal cortex in each of the phases examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Subjects with stroke\u2010related LUTS exhibit a specific pattern of brain activity during bladder filling and voiding. There appears to be a greater reliance on primitive centers (cerebellum, midbrain) than in healthy controls during both phases of the micturition cycle. We hypothesize that these findings may reflect loss of connectivity with higher brain centers after a stroke.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24473","type":"journal-article","created":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T00:02:26Z","timestamp":1596758546000},"page":"2198-2205","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The effect of stroke on micturition associated brain activity: A pilot fMRI study"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8207-3809","authenticated-orcid":false,"given":"Evgeniy I.","family":"Kreydin","sequence":"first","affiliation":[{"name":"Department of Urology Keck School of Medicine of University of Southern California Los Angeles California"},{"name":"Department of Neurological Surgery Keck School of Medicine of University of Southern California Los Angeles California"},{"name":"USC Neurorestoration Center University 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