{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T23:52:26Z","timestamp":1778802746249,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005170","name":"Ohio Department of Development","doi-asserted-by":"publisher","award":["W81XWH\u201017\u20101\u20100403"],"award-info":[{"award-number":["W81XWH\u201017\u20101\u20100403"]}],"id":[{"id":"10.13039\/100005170","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To examine vibegron effects on lower urinary tract dysfunction (LUTD) in mice with spinal cord injury (SCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Female mice underwent Th8\u20109 spinal cord transection and were orally administered vehicle or vibegron after SCI. We evaluated urodynamic parameters at 4 weeks after SCI with or without vibegron. Fibrosis\u2010 and ischemia\u2010related messenger RNA (mRNA) and protein levels of collagen and elastin were measured in bladders of vehicle\u2010 and vibegron\u2010treated SCI mice, and spinal intact mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Non\u2010voiding contractions (NVCs) were significantly fewer (15.3\u2009\u00b1\u20098.9 vs 29.7\u2009\u00b1\u200911.4 contractions; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05) and the time to the first NVC was significantly longer (1488.0\u2009\u00b1\u2009409.5 vs 782.7\u2009\u00b1\u2009399.7\u2009seconds; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01) in vibegron\u2010treated SCI mice vs vehicle\u2010treated SCI mice. mRNAs levels of collagen types 1 and 3, transforming growth factor\u2010\u03b21 (TGF\u2010\u03b21), and hypoxia\u2010inducible factor\u20101\u03b1 (HIF\u20101\u03b1) were significantly upregulated in vehicle\u2010treated SCI mice compared with spinal intact and vibegron\u2010treated SCI mice (Col 1: 3.5 vs 1.0 and 2.0\u2010fold; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01 and <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05, Col 3: 2.1 vs 1.0 and 1.2\u2010fold; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01 and <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05, TGF\u2010\u03b21: 1.2 vs 1.0 and 0.9\u2010fold; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05 and <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05, HIF\u20101\u03b1: 1.4 vs 1.0 and 1.0\u2010fold; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05 and <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01). Total collagen and elastin protein levels in vehicle\u2010 and vibegron\u2010treated SCI mice did not differ.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Vibegron reduced NVCs, delayed the first NVC, and improved collagen types 1 and 3, TGF\u2010\u03b21, and HIF\u20101\u03b1 mRNA expression in SCI mice. Vibegron might be effective for SCI\u2010induced LUTD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24486","type":"journal-article","created":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T15:51:32Z","timestamp":1597938692000},"page":"2120-2127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Effects of a new \u03b23\u2010adrenoceptor agonist, vibegron, on neurogenic bladder dysfunction and remodeling in mice with spinal cord injury"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6056-3820","authenticated-orcid":false,"given":"Daisuke","family":"Gotoh","sequence":"first","affiliation":[{"name":"Department of Urology University of Pittsburgh Pittsburgh Pennsylvania"},{"name":"Department of Urology Nara Medical University Kashihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobutaka","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Urology University of Pittsburgh Pittsburgh Pennsylvania"},{"name":"Department of Urology, Faculty of Medicine Kindai University Osaka\u2010Sayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9587-6798","authenticated-orcid":false,"given":"Naoki","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Urology University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsumi","family":"Kadekawa","sequence":"additional","affiliation":[{"name":"Department of Urology University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuichi","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Urology University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsuke","family":"Mizoguchi","sequence":"additional","affiliation":[{"name":"Department of Urology University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7142-5901","authenticated-orcid":false,"given":"Yosuke","family":"Morizawa","sequence":"additional","affiliation":[{"name":"Department of Urology Nara Medical University Kashihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunta","family":"Hori","sequence":"additional","affiliation":[{"name":"Department of Urology Nara Medical University Kashihara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makito","family":"Miyake","sequence":"additional","affiliation":[{"name":"Department of Urology Nara Medical University Kashihara 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