{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T17:58:50Z","timestamp":1759773530076,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T00:00:00Z","timestamp":1599177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To examine whether isolated bladder outlet obstruction in the absence of associated lower urinary tract abnormality results in hydronephrosis. Isolated obstruction causes a brief rise in bladder pressure that might not trigger hydronephrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data included adult men who underwent urodynamics for refractory non\u2010neurogenic lower tract symptoms between 2011 and 2020. International Continence Society indices for obstruction (bladder outlet obstruction index [BOOI]\u2009\u2265\u200940) and underactivity (bladder contractility index [BCI]\u2009&lt;\u2009100) were calculated. Storage abnormality was defined as detrusor overactivity (DO) or poor compliance (&lt;20\u2009ml\/cm\u2009H<jats:sub>2<\/jats:sub>0). Isolated obstruction was defined as BOOI\u2009\u2265\u200940, BCI\u2009\u2265\u2009100 and no storage abnormality. Nonparametric tests using R program (3.5.0) applied (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05 significant). Logistic regression analyses were performed to study the relationships of hydronephrosis with lower urinary tract function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total 1596 men (range, 18\u201391 years; median, 51.0 years; Q3, 64.0 years; Q1, 34.0 years) were eligible. Hydronephrosis was noted in 274 (17.2%). A total of 45.4% were obstructed, 52.3% were underactive and 41.7% had storage abnormality. Storage abnormality (odds ratios [OR], 2.05; 95% confidence interval [CI]: 1.56, 2.69; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and bladder contractility (OR, 1.68; 95% CI, 1.25\u20132.26; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) but not obstruction (OR, 1.07; 95% CI, 0.80\u20131.44; <jats:italic>p<\/jats:italic>\u2009=\u2009.634) was associated with hydronephrosis. Of eight possible combinations, men with BOO\u2009\u2265\u200940, BCI\u2009\u2265\u2009100 and storage abnormality had highest probability of hydronephrosis (OR, 0.29; 95% CI, 0.24\u20130.33). Subanalysis showed that poor compliance (OR, 3.39; 95% CI, 2.49\u20134.60; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) but not DO was associated with hydronephrosis. Younger age and higher postvoid residual urine were also associated with hydronephrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In adult men with refractory non\u2010neurogenic lower urinary tract symptoms, isolated bladder outlet obstruction is not associated with hydronephrosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/nau.24495","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T17:52:06Z","timestamp":1599241926000},"page":"2361-2367","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Is isolated bladder outlet obstruction associated with hydronephrosis? A database analysis"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7090-2091","authenticated-orcid":false,"given":"Sanjay","family":"Sinha","sequence":"first","affiliation":[{"name":"Department of Urology Apollo Hospital  Hyderabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lavina","family":"Matai","sequence":"additional","affiliation":[{"name":"Department of Urology Apollo Hospital  Hyderabad India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,4]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_6_2_1","DOI":"10.1016\/S0022-5347(17)69191-2"},{"doi-asserted-by":"publisher","key":"e_1_2_6_3_1","DOI":"10.1016\/j.urology.2018.04.010"},{"key":"e_1_2_6_4_1","first-page":"2504","volume-title":"Campbell\u2010Walsh Urology","author":"Welliver C","year":"2016"},{"doi-asserted-by":"publisher","key":"e_1_2_6_5_1","DOI":"10.1002\/nau.23124"},{"doi-asserted-by":"publisher","key":"e_1_2_6_6_1","DOI":"10.1046\/j.1464-410x.1999.00121.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_7_1","DOI":"10.1097\/00005392-199707000-00059"},{"doi-asserted-by":"publisher","key":"e_1_2_6_8_1","DOI":"10.1002\/nau.21095"},{"key":"e_1_2_6_9_1","first-page":"215","article-title":"Can we identify men who will have complications from benign prostatic obstruction (BPO)? ICI\u2010RS 2011 Matthias","volume":"32","author":"Oelke M","year":"2013","journal-title":"Neurourol Urodyn"},{"doi-asserted-by":"publisher","key":"e_1_2_6_10_1","DOI":"10.1023\/A:1007115013407"},{"key":"e_1_2_6_11_1","first-page":"1","article-title":"Diagnostic value of urodynamic bladder outlet obstruction to select patients for transurethral surgery of the prostate: systematic review and meta\u2010analysis","volume":"12","author":"Kim M","year":"2017","journal-title":"PLOS One"},{"doi-asserted-by":"publisher","key":"e_1_2_6_12_1","DOI":"10.1097\/MOU.0000000000000496"},{"doi-asserted-by":"publisher","key":"e_1_2_6_13_1","DOI":"10.1016\/S0022-5347(05)64846-X"},{"doi-asserted-by":"publisher","key":"e_1_2_6_14_1","DOI":"10.1016\/j.urology.2007.03.063"},{"doi-asserted-by":"publisher","key":"e_1_2_6_15_1","DOI":"10.4111\/icu.2016.57.6.437"},{"key":"e_1_2_6_16_1","first-page":"E157","article-title":"Canadian urological association guideline: diagnosis, management, and surveillance of neurogenic lower urinary tract dysfunction","volume":"13","author":"Kavanagh A","year":"2019","journal-title":"Can Urol Assoc J"},{"doi-asserted-by":"publisher","key":"e_1_2_6_17_1","DOI":"10.1159\/000052505"},{"doi-asserted-by":"publisher","key":"e_1_2_6_18_1","DOI":"10.1002\/nau.22671"},{"doi-asserted-by":"publisher","key":"e_1_2_6_19_1","DOI":"10.1002\/nau.24076"},{"doi-asserted-by":"publisher","key":"e_1_2_6_20_1","DOI":"10.1080\/03008880410015453"},{"doi-asserted-by":"publisher","key":"e_1_2_6_21_1","DOI":"10.1016\/S0022-5347(05)65862-4"},{"doi-asserted-by":"publisher","key":"e_1_2_6_22_1","DOI":"10.1038\/nrurol.2014.156"},{"doi-asserted-by":"publisher","key":"e_1_2_6_23_1","DOI":"10.1016\/j.eururo.2009.02.026"},{"doi-asserted-by":"publisher","key":"e_1_2_6_24_1","DOI":"10.3390\/nu11071539"},{"doi-asserted-by":"publisher","key":"e_1_2_6_25_1","DOI":"10.1002\/nau.23778"},{"doi-asserted-by":"publisher","key":"e_1_2_6_26_1","DOI":"10.1016\/S0022-5347(01)67138-6"},{"doi-asserted-by":"publisher","key":"e_1_2_6_27_1","DOI":"10.1002\/nau.23773"}],"container-title":["Neurourology and Urodynamics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.24495","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/nau.24495","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/nau.24495","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T01:45:30Z","timestamp":1692841530000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/nau.24495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,4]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1002\/nau.24495"],"URL":"https:\/\/doi.org\/10.1002\/nau.24495","archive":["Portico"],"relation":{},"ISSN":["0733-2467","1520-6777"],"issn-type":[{"type":"print","value":"0733-2467"},{"type":"electronic","value":"1520-6777"}],"subject":[],"published":{"date-parts":[[2020,9,4]]},"assertion":[{"value":"2020-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}