{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:02:02Z","timestamp":1787497322631,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Neurourology and Urodynamics"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Local anesthesia protocols for intradetrusor onabotulinum toxin A (BoNTA) injection lack standardization. We aimed to determine if an alkalinized lidocaine solution is more effective than lidocaine only.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients of both genders aged 18 or above enlisted for intradetrusor BoNTA injection (idiopathic, neurogenic, and bladder pain syndrome) were included in a double\u2010blinded randomized controlled trial after obtaining their informed consent. All participants filled a bladder diary and a urine culture was performed. Subjects were randomized 1:1 to Protocol A (20\u2009ml 2% lidocaine\u2009+\u200910\u2009ml 8.4% sodium bicarbonate) or Protocol B (20\u2009ml 2% lidocaine\u2009+\u200910\u2009ml 0.9% saline solution). A Numeric Rating Scale (0\u201310) was used to assess the level of pain immediately after the procedure (primary endpoint). Secondary endpoints included pain after 1\u2009h, urinary tract infection, acute urinary retention, and hematuria related to the procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 116 patients were randomized. Baseline characteristics (age, sex, indication, and bladder diary parameters) of patients in Group A and B were similar. Pain scores at the end of the procedure were significantly lower with the alkalinized solution (Protocol A and B, respectively, 2.37\u2009\u00b1\u20090.31 vs. 4.44\u2009\u00b1\u20090.36,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01). No differences were observed 1\u2009h after treatment (Protocol A and B, respectively, 0.54\u2009\u00b1\u20090.17 vs. 0.69\u2009\u00b1\u20090.19,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.487). The only adverse event reported was mild\u2010to\u2010moderate self\u2010limited hematuria in 15.4% of patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The use of an alkalinized lidocaine solution has proven to be significantly superior to lidocaine only as local anesthesia before intradetrusor BoNTA injection, suggesting that this may be considered a first\u2010line option.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/nau.24519","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T16:34:34Z","timestamp":1600706074000},"page":"2471-2479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Alkalinized lidocaine solution as a first\u2010line local anesthesia protocol for intradetrusor injection of onabotulinum toxin A: Results from a double\u2010blinded randomized controlled trial"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4396-4921","authenticated-orcid":false,"given":"Ricardo","family":"Pereira e Silva","sequence":"first","affiliation":[{"name":"Department of Urology Centro Hospitalar Universit\u00e1rio Lisboa Norte Lisboa Portugal"},{"name":"Cl\u00ednica Universit\u00e1ria de Urologia Faculdade de Medicina Universidade de Lisboa Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Ponte","sequence":"additional","affiliation":[{"name":"Department of Urology Centro Hospitalar Universit\u00e1rio Lisboa Norte Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipe","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Urology Centro Hospitalar Universit\u00e1rio Lisboa Norte Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Palma dos Reis","sequence":"additional","affiliation":[{"name":"Department of Urology Centro Hospitalar Universit\u00e1rio Lisboa Norte Lisboa Portugal"},{"name":"Cl\u00ednica Universit\u00e1ria de Urologia Faculdade de Medicina Universidade de Lisboa Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2016.03.146"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2019.12.001"},{"issue":"7","key":"e_1_2_8_4_1","first-page":"635","article-title":"Intravesical botulinum toxin under local anestesia as ambulatory procedure","volume":"70","author":"Fabuel Alca\u00f1iz JJ","year":"2017","journal-title":"Arch Esp Urol"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22750"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.06.004"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2017.11.016"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)66238-6"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2008.08162.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.09.007"},{"key":"e_1_2_8_11_1","unstructured":"BlokB Castro\u2010DiazD Del PopoloG et alEuropean Association of Urology Guidelines. 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